Nanoparticle-and microparticle-based vaccines against orbiviruses of veterinary importance

L Jiménez-Cabello, S Utrilla-Trigo, N Barreiro-Piñeiro… - Vaccines, 2022 - mdpi.com
Bluetongue virus (BTV) and African horse sickness virus (AHSV) are widespread
arboviruses that cause important economic losses in the livestock and equine industries …

The Potential of Plant-Produced Virus-like Particle Vaccines for African Horse Sickness and Other Equine Orbiviruses

KG Pitchers, OD Boakye, I Campeotto, JM Daly - Pathogens, 2024 - mdpi.com
African horse sickness is a devastating viral disease of equids. It is transmitted by biting
midges of the genus Culicoides with mortalities reaching over 90% in naïve horses. It is …

New generation of African horse sickness virus vaccines based on structural and molecular studies of the virus particles

P Roy, G Sutton - African Horse Sickness, 1998 - Springer
African horse sickness virus (AHSV) is a member of the genus Orbivirus, which also includes
bluetongue virus (BTV) and epizootic haemorrhagic disease (EHDV) virus. These …

Generation of virus-like particles for emerging epizootic haemorrhagic disease virus: Towards the development of safe vaccine candidates

K Alshaikhahmed, P Roy - Vaccine, 2016 - Elsevier
Epizootic haemorrhagic disease virus (EHDV) is an insect-transmitted pathogen which
causes high mortality in deer populations and may also cause high morbidity in cattle. EHDV …

Characterization of protection afforded by a bivalent virus-like particle vaccine against bluetongue virus serotypes 1 and 4 in sheep

AC Pérez de Diego, TN Athmaram, M Stewart… - PloS one, 2011 - journals.plos.org
Background Bluetongue virus (BTV) is an economically important, arthropod borne,
emerging pathogen in Europe, causing disease mainly in sheep and cattle. Routine …

Microspheres-prime/rMVA-boost vaccination enhances humoral and cellular immune response in IFNAR (−/−) mice conferring protection against serotypes 1 and 4 of …

A Marín-López, E Calvo-Pinilla, D Barriales, G Lorenzo… - Antiviral Research, 2017 - Elsevier
Bluetongue virus (BTV) is the causative agent of bluetongue disease (BT), which affects
domestic and wild ruminants. At the present, 27 different serotypes have been documented …

Viral vector vaccines against bluetongue virus

L Jiménez-Cabello, S Utrilla-Trigo, E Calvo-Pinilla… - Microorganisms, 2020 - mdpi.com
Bluetongue virus (BTV), the prototype member of the genus Orbivirus (family Reoviridae), is
the causative agent of an important livestock disease, bluetongue (BT), which is transmitted …

Nanoparticle orientationally displayed antigen epitopes improve neutralizing antibody level in a model of porcine circovirus type 2

P Ding, T Zhang, Y Li, M Teng, Y Sun… - International Journal …, 2017 - Taylor & Francis
Recent advancements in biotechnology have enabled the rapid identification and
subsequent expression of pathogenic microbial major antigens that induce protective …

Genetically engineered particulate virus-like structures and their use as vaccine delivery systems

P Roy - Intervirology, 1996 - karger.com
The Orbivirus genus within the family Reoviridae consists of nonenveloped architecturally
complex viruses. The icosahedral viruses are 810 A diameter in size and are comprised of …

Protective efficacy in sheep of adenovirus-vectored vaccines against bluetongue virus is associated with specific T cell responses

V Martín, E Pascual, M Avia, L Pena, F Valcarcel… - PLoS …, 2015 - journals.plos.org
Bluetongue virus (BTV) is an economically important Orbivirus of the Reoviridae family that
causes a hemorrhagic disease in ruminants. Its control has been achieved by inactivated …