SPOC domain proteins in health and disease
LM Appel, J Benedum, M Engl, S Platzer… - Genes & …, 2023 - genesdev.cshlp.org
Since it was first described> 20 yr ago, the SPOC domain (Spen paralog and ortholog C-
terminal domain) has been identified in many proteins all across eukaryotic species. SPOC …
terminal domain) has been identified in many proteins all across eukaryotic species. SPOC …
Deregulation of SPOP in cancer
H Zhang, X Jin, H Huang - Cancer research, 2023 - AACR
Speckle-type POZ protein (SPOP) is a substrate-binding adaptor of the CULLIN3/RING-box1
E3 ubiquitin ligase complex. SPOP is frequently mutated in prostate and endometrial …
E3 ubiquitin ligase complex. SPOP is frequently mutated in prostate and endometrial …
SPOP in Cancer: Phenomena, mechanisms and its role in therapeutic implications
X Yang, Q Zhu - Genes, 2022 - mdpi.com
Speckle-type POZ (pox virus and zinc finger protein) protein (SPOP) is a cullin 3-based E3
ubiquitin ligase adaptor protein that plays a crucial role in ubiquitin-mediated protein …
ubiquitin ligase adaptor protein that plays a crucial role in ubiquitin-mediated protein …
The emerging role of SPOP protein in tumorigenesis and cancer therapy
Y Song, Y Xu, C Pan, L Yan, Z Wang, X Zhu - Molecular Cancer, 2020 - Springer
The nuclear speckle-type pox virus and zinc finger (POZ) protein (SPOP), a representative
substrate-recognition subunit of the cullin-RING E3 ligase, has been characterized to play a …
substrate-recognition subunit of the cullin-RING E3 ligase, has been characterized to play a …
SPOC1: a novel PHD-containing protein modulating chromatin structure and mitotic chromosome condensation
S Kinkley, H Staege, G Mohrmann… - Journal of cell …, 2009 - journals.biologists.com
In this study, we characterize the molecular and functional features of a novel protein called
SPOC1. SPOC1 RNA expression was previously reported to be highest in highly …
SPOC1. SPOC1 RNA expression was previously reported to be highest in highly …
[HTML][HTML] SPOP and cancer: a systematic review
A Clark, M Burleson - American Journal of Cancer Research, 2020 - ncbi.nlm.nih.gov
The initiation and progression of cancer is dependent on the acquisition of mutations in
oncogenes or tumor suppressor genes that ultimately leads to the dysregulation of key …
oncogenes or tumor suppressor genes that ultimately leads to the dysregulation of key …
The diverse roles of SPOP in prostate cancer and kidney cancer
Multiple studies have confirmed that speckle-type pox virus and zinc finger (POZ) protein
(SPOP) functions as a substrate adaptor of cullin 3-based E3 ligase and has a crucial role in …
(SPOP) functions as a substrate adaptor of cullin 3-based E3 ligase and has a crucial role in …
Mutational and expressional analyses of SPOP, a candidate tumor suppressor gene, in prostate, gastric and colorectal cancers
MS Kim, EM Je, JE Oh, NJ Yoo, SH Lee - Apmis, 2013 - Wiley Online Library
Mounting evidence exists that alterations of ubiquitination processes are involved in cancer
pathogenesis. Speckle‐type POZ protein (SPOP) is a key adaptor for Cul3‐based …
pathogenesis. Speckle‐type POZ protein (SPOP) is a key adaptor for Cul3‐based …
[HTML][HTML] Novel insights into the SPOP E3 ubiquitin ligase: From the regulation of molecular mechanisms to tumorigenesis
XM Li, HL Wu, QD Xia, P Zhou, SG Wang, X Yu… - Biomedicine & …, 2022 - Elsevier
Ubiquitin-mediated protein degradation is the primary biological process by which protein
abundance is regulated and protein homeostasis is maintained in eukaryotic cells. Speckle …
abundance is regulated and protein homeostasis is maintained in eukaryotic cells. Speckle …
The ubiquitin ligase adaptor SPOP in cancer
The dysregulation of ubiquitin‐mediated proteasomal degradation has emerged as an
important mechanism of pathogenesis in several cancers. The speckle‐type POZ protein …
important mechanism of pathogenesis in several cancers. The speckle‐type POZ protein …