Biologic therapies that target pathogenic cytokines such as TNF, IL-1β or IL-6 have greatly
improved the treatment of RA. Unfortunately, not all RA patients respond to current biologic …

Over the past few years, the importance of Interleukin (IL)-17 and T helper (Th) 17 cells in
the pathology of Rheumatoid Arthritis (RA) has become apparent. RA is a systemic …

CD4+ T cells differentiate into distinct subsets with unique functions and patterns of cytokine
secretion, such as the subsets termed Th1 and Th2. 1 Th1 cells produce interferon (IFN)-g …

Interleukin-17A (IL-17A) contributes to the pathogenesis of arthritis. Data from experimental
arthritis indicate IL-17 receptor signaling as a critical pathway in turning an acute synovitis …

Th17 cells are implicated in human autoimmune diseases, such as rheumatoid arthritis (RA),
although it has not been established whether this persistent destructive arthritis is driven by …

Abstract T helper 17 (Th17) cells are important mediators of immune responses against
extracellular bacteria and fungi, and as such play critical regulatory roles in maintaining …

Recent therapeutic advancements in understanding of molecular and cellular mechanisms
of rheumatoid arthritis (RA) have highlighted the strategies that aim to inhibit the harmful …

abstract Importance Accumulating evidence suggests that IL-17 A has broad pathogenic
roles in multiple autoimmune and immune-mediated inflammatory diseases, including …

The discovery that the IL-23–IL-17 immune pathway is involved in many models of
autoimmune disease has changed the concept of the role of T-helper cell subsets in the …

While T cells have been implicated in the pathogenesis of inflammatory arthritis for more
than three decades, the focus on the T helper type 17 (Th17) subset of CD4 T cells and their …