Collective cancer invasion with leader–follower organization is increasingly recognized as a
predominant mechanism in the metastatic cascade. Leader cells support cancer invasion by …

Collective cell migrations drive morphogenesis, wound healing, and cancer dissemination.
Cells located at the front are considered leaders while those behind them are defined …

Collective migration is a basic mechanism of celltranslocation during morphogenesis,
wound repair and cancer invasion. Collective movement requires cells to retain cell–cell …

The ability of primary tumor cells to invade into adjacent tissues, followed by the formation of
local or distant metastasis, is a lethal hallmark of cancer. Recently, locomoting clusters of …

Most invasive solid tumours display predominantly collective invasion, in which groups of
cells invade the peritumoral stroma while maintaining cell–cell contacts. As the concepts …

Phenotypic heterogeneity is widely observed in cancer cell populations. Here, to probe this
heterogeneity, we developed an image-guided genomics technique termed spatiotemporal …

Cancer is a disease of extreme heterogeneity. Microarray analysis has identified thousands
of genes that are transcriptionally up-or down-regulated in tumor samples; molecularly …

Carcinomas typically invade as a cohesive multicellular unit, a process termed collective
invasion. It remains unclear how different subpopulations of cancer cells contribute to this …

Solid tumors consist of genetically and phenotypically diverse subpopulations of cancer
cells with unique capacities for growth, differentiation, and invasion. While the molecular and …

Tumor cells can engage in a process called collective invasion, in which cohesive groups of
cells invade through interstitial tissue. Here, we identified an epigenetically distinct …