MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy
AL Kasinski, FJ Slack - Nature Reviews Cancer, 2011 - nature.com
In normal cells multiple microRNAs (miRNAs) converge to maintain a proper balance of
various processes, including proliferation, differentiation and cell death. miRNA …
various processes, including proliferation, differentiation and cell death. miRNA …
microRNA therapies in cancer
SI Rothschild - Molecular and cellular therapies, 2014 - Springer
MicroRNAs (miRNAs or miRs) are a family of small non-coding RNA species that have been
implicated in the control of many fundamental cellular and physiological processes such as …
implicated in the control of many fundamental cellular and physiological processes such as …
Targeting microRNAs in cancer: rationale, strategies and challenges
MicroRNAs (miRNAs) are evolutionarily conserved small non-coding RNAs that regulate
gene expression. Early studies have shown that miRNA expression is deregulated in cancer …
gene expression. Early studies have shown that miRNA expression is deregulated in cancer …
MicroRNAs in cancer
G Di Leva, M Garofalo, CM Croce - Annual Review of Pathology …, 2014 - annualreviews.org
MicroRNAs (miRNAs) are small noncoding RNAs that typically inhibit the translation and
stability of messenger RNAs (mRNAs), controlling genes involved in cellular processes such …
stability of messenger RNAs (mRNAs), controlling genes involved in cellular processes such …
[HTML][HTML] Modulating microRNAs in cancer: Next-generation therapies
N Arghiani, K Shah - Cancer Biology & Medicine, 2022 - ncbi.nlm.nih.gov
MicroRNAs (miRNAs) are a class of endogenously expressed non-coding regulators of the
genome with an ability to mediate a variety of biological and pathological processes. There …
genome with an ability to mediate a variety of biological and pathological processes. There …
Developing therapeutic microRNAs for cancer
AG Bader, D Brown, J Stoudemire, P Lammers - Gene therapy, 2011 - nature.com
Despite substantial progress in understanding the cancer-signaling network, effective
therapies remain scarce due to insufficient disruption of oncogenic pathways, drug …
therapies remain scarce due to insufficient disruption of oncogenic pathways, drug …
The therapeutic potential of microRNAs in cancer
SB Thorsen, S Obad, NF Jensen, J Stenvang… - The Cancer …, 2012 - journals.lww.com
MicroRNAs (miRNAs) have been uncovered as important posttranscriptional regulators of
nearly every biological process in the cell. Furthermore, mounting evidence implies that …
nearly every biological process in the cell. Furthermore, mounting evidence implies that …
The road toward microRNA therapeutics
AG Seto - The international journal of biochemistry & cell biology, 2010 - Elsevier
Within the last 15 years, microRNAs (miRNAs) have emerged as powerful regulators of gene
expression. Highly conserved, these small RNAs appear to regulate nearly every aspect of …
expression. Highly conserved, these small RNAs appear to regulate nearly every aspect of …
MicroRNAs in cancer—from research to therapy
WCS Cho - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2010 - Elsevier
MicroRNAs (miRNAs) regulate target gene expression through translation repression or
mRNA degradation. These non-coding RNAs are emerging as important modulators in …
mRNA degradation. These non-coding RNAs are emerging as important modulators in …
Therapeutic targeting of microRNAs in cancer: future perspectives
ABSTRACT Preclinical Research The discovery of microRNAs (miRNAs) and their link with
cancer has opened a new era in cancer therapeutics. Approximately, 18− 24 nucleotides …
cancer has opened a new era in cancer therapeutics. Approximately, 18− 24 nucleotides …