Melanoma incidence and mortality rates are historically higher for men than women.
Although emerging studies have highlighted tumorigenic roles for the male sex hormone …

Melanoma incidence and mortality rates are historically higher for men than women.
Although emerging studies have highlighted tumorigenic roles for the male sex hormone …

Early studies demonstrated that male melanoma patients have worse survival than female
patients, yet the detailed mechanisms for this gender difference remain unclear. We …

Androgen receptor (AR) is expressed in numerous tissues and serves important biologic
functions in skin, prostate, immune, cardiovascular, and neural systems, alongside sexual …

Androgen receptor (AR) is expressed in numerous tissues and serves important biologic
functions in skin, prostate, immune, cardiovascular, and neural systems, alongside sexual …

Melanoma susceptibility differs significantly in male versus female populations. Low levels of
androgen receptor (AR) in melanocytes of the two sexes are accompanied by …

Acral melanoma (AM) is a rare subtype of melanoma characterized by a high incidence of
lymph node (LN) metastasis, a critical factor in tumor dissemination and therapeutic decision …

Background The recurrent BRAF driver mutation V600E (BRAF V600E) is currently one of
the most clinically relevant mutations in melanoma. However, the genome-wide …

PBAF is a mammalian chromatin-remodeling complex of the SWI/SNF family, essential for
transcriptional regulation and development, which is frequently mutated in cancer. In …

Chromatin deregulation is an emerging hallmark of cancer. However, the extent of
epigenetic aberrations during tumorigenesis and their relationship with genetic aberrations …