Background: COPDGene is a multicenter observational study designed to identify genetic
factors associated with COPD. It will also characterize chest CT phenotypes in COPD …

Background There is notable heterogeneity in the clinical presentation of patients with
COPD. To characterise this heterogeneity, we sought to identify subgroups of smokers by …

The Genetic Epidemiology of COPD (COPDGene) study is a noninterventional, multicenter,
longitudinal analysis of> 10,000 subjects, including smokers with a≥ 10 pack-year history …

Chronic obstructive pulmonary disease (COPD) is a common and progressive disease that
is influenced by both genetic and environmental factors. For many years, knowledge of the …

A genetic contribution to develop chronic obstructive pulmonary disease (COPD) is well
established. However, the specific genes responsible for enhanced risk or host differences …

Background Studies have shown that family history is a risk factor for COPD, but have not
accounted for family history of smoking. Therefore, we sought to identify the effects of family …

Chronic obstructive pulmonary disease (COPD) is a significant cause of global morbidity
and mortality. Previous studies have shown that COPD aggregates in families, suggesting a …

COPD is a common complex disease characterized by progressive airflow limitation.
Several genome-wide association studies (GWASs) have discovered genes that are …

Rationale: Previous studies of chronic obstructive pulmonary disease (COPD) have
suggested that genetic factors play an important role in the development of disease …

Familial aggregation of chronic obstructive pulmonary disease (COPD) has been
demonstrated, suggesting that genetic factors likely influence the variable development of …