Genetic disruption of system xc-mediated glutamate release from astrocytes increases negative-outcome behaviors while preserving basic brain function in rat
The importance of neuronal glutamate to synaptic transmission throughout the brain
illustrates the immense therapeutic potential and safety risks of targeting this system …
illustrates the immense therapeutic potential and safety risks of targeting this system …
[HTML][HTML] Sex-and age-dependent contribution of System xc–to cognitive, sensory, and social behaviors revealed by comprehensive behavioral analyses of System xc …
Background System xc–(Sxc–) is an important heteromeric amino acid cystine/glutamate
exchanger that plays a pivotal role in the CNS by importing cystine into cells while exporting …
exchanger that plays a pivotal role in the CNS by importing cystine into cells while exporting …
Behavioral assessment of acute inhibition of system xc - in rats
V Lutgen, J Resch, K Qualmann, NJ Raddatz… - …, 2014 - Springer
Rationale Gaps in our understanding of glutamatergic signaling may be key obstacles in
accurately modeling complex CNS diseases. System xc-is an example of a poorly …
accurately modeling complex CNS diseases. System xc-is an example of a poorly …
Absence of system xc-in mice decreases anxiety and depressive-like behavior without affecting sensorimotor function or spatial vision
E Bentea, T Demuyser, J Van Liefferinge… - Progress in Neuro …, 2015 - Elsevier
There is considerable preclinical and clinical evidence indicating that abnormal changes in
glutamatergic signaling underlie the development of mood disorders. Astrocytic glutamate …
glutamatergic signaling underlie the development of mood disorders. Astrocytic glutamate …
Regulation of hippocampal synaptic strength by glial xCT
LE Williams, DE Featherstone - Journal of Neuroscience, 2014 - Soc Neuroscience
Most extracellular glutamate in the brain is released by xCT, a glial antiporter that exports
glutamate and imports cystine. The function of xCT, and extracellular glutamate in general …
glutamate and imports cystine. The function of xCT, and extracellular glutamate in general …
Main path and byways: non‐vesicular glutamate release by system xc− as an important modifier of glutamatergic neurotransmission
A Massie, S Boillee, S Hewett… - Journal of …, 2015 - Wiley Online Library
Abstract System xc− is a cystine/glutamate antiporter that exchanges extracellular cystine for
intracellular glutamate. Cystine is intracellularly reduced to cysteine, a building block of …
intracellular glutamate. Cystine is intracellularly reduced to cysteine, a building block of …
Hyperexcitability and brain morphological differences in mice lacking the cystine/glutamate antiporter, system xc−
SMS Sears, SH Roberts… - Journal of neuroscience …, 2021 - Wiley Online Library
Abstract System xc−(Sxc−) is a heteromeric antiporter (L‐cystine/L‐glutamate exchanger)
expressed predominately on astrocytes in the central nervous system. Its activity contributes …
expressed predominately on astrocytes in the central nervous system. Its activity contributes …
[HTML][HTML] Targeting glia with N-acetylcysteine modulates brain glutamate and behaviors relevant to neurodevelopmental disorders in C57BL/6J mice
AMS Durieux, C Fernandes, D Murphy… - Frontiers in behavioral …, 2015 - frontiersin.org
An imbalance between excitatory (E) glutamate and inhibitory (I) GABA transmission may
underlie neurodevelopmental conditions such as autism spectrum disorder (ASD) and …
underlie neurodevelopmental conditions such as autism spectrum disorder (ASD) and …
Loss of system xc− does not induce oxidative stress but decreases extracellular glutamate in hippocampus and influences spatial working memory and limbic seizure …
D De Bundel, A Schallier, E Loyens… - Journal of …, 2011 - Soc Neuroscience
System xc− exchanges intracellular glutamate for extracellular cystine, giving it a potential
role in intracellular glutathione synthesis and nonvesicular glutamate release. We report that …
role in intracellular glutathione synthesis and nonvesicular glutamate release. We report that …
[HTML][HTML] Loss of functional system xc uncouples aberrant postnatal neurogenesis from epileptogenesis in the hippocampus of Kcna1-KO mice
MS Aloi, SJ Thompson, N Quartapella, JL Noebels - Cell reports, 2022 - cell.com
Summary Mutations in Kv1. 1 (Kcna1) voltage-gated potassium channels in humans and
mice generate network hyperexcitability, enhancing aberrant postnatal neurogenesis in the …
mice generate network hyperexcitability, enhancing aberrant postnatal neurogenesis in the …