SARS-CoV-2 virus NSP14 Impairs NRF2/HMOX1 activation by targeting Sirtuin 1
Most deaths from the COVID-19 pandemic are due to acute respiratory distress syndrome
(ARDS)-related respiratory failure. Cytokine storms and oxidative stress are the major …
(ARDS)-related respiratory failure. Cytokine storms and oxidative stress are the major …
SARS-CoV-2 nsp12 attenuates type I interferon production by inhibiting IRF3 nuclear translocation
W Wang, Z Zhou, X Xiao, Z Tian, X Dong… - Cellular & molecular …, 2021 - nature.com
SARS-CoV-2 is the pathogenic agent of COVID-19, which has evolved into a global
pandemic. Compared with some other respiratory RNA viruses, SARS-CoV-2 is a poor …
pandemic. Compared with some other respiratory RNA viruses, SARS-CoV-2 is a poor …
HIF-1α promotes SARS-CoV-2 infection and aggravates inflammatory responses to COVID-19
M Tian, W Liu, X Li, P Zhao, MA Shereen… - … and Targeted Therapy, 2021 - nature.com
Cytokine storm induced by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-
2) is a major pathological feature of Coronavirus Disease 2019 (COVID-19) and a crucial …
2) is a major pathological feature of Coronavirus Disease 2019 (COVID-19) and a crucial …
SARS-CoV-2 viral proteins NSP1 and NSP13 inhibit interferon activation through distinct mechanisms
C Vazquez, SE Swanson, SG Negatu, M Dittmar… - PloS one, 2021 - journals.plos.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a devastating
global pandemic, infecting over 43 million people and claiming over 1 million lives, with …
global pandemic, infecting over 43 million people and claiming over 1 million lives, with …
Potential role of antioxidant and anti-inflammatory therapies to prevent severe SARS-Cov-2 complications
AM Fratta Pasini, C Stranieri, L Cominacini, C Mozzini - Antioxidants, 2021 - mdpi.com
The coronavirus disease 2019 (COVID-19) pandemic is caused by a novel severe acute
respiratory syndrome (SARS)-like coronavirus (SARS-CoV-2). Here, we review the …
respiratory syndrome (SARS)-like coronavirus (SARS-CoV-2). Here, we review the …
SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate
D Olagnier, E Farahani, J Thyrsted… - Nature …, 2020 - nature.com
Antiviral strategies to inhibit Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-
CoV2) and the pathogenic consequences of COVID-19 are urgently required. Here, we …
CoV2) and the pathogenic consequences of COVID-19 are urgently required. Here, we …
SARS-CoV-2 switches 'on'MAPK and NFκB signaling via the reduction of nuclear DUSP1 and DUSP5 expression
S Goel, F Saheb Sharif-Askari… - Frontiers in …, 2021 - frontiersin.org
Mitogen-activated protein kinases (MAPK) and NF-kappaB (NF-κB) pathway regulate many
cellular processes and are essential for immune cells function. Their activity is controlled by …
cellular processes and are essential for immune cells function. Their activity is controlled by …
SARS-CoV-2 inhibits NRF2-mediated antioxidant responses in airway epithelial cells and in the lung of a murine model of infection
Several viruses have been shown to modulate the transcription factor nuclear factor
erythroid 2-related factor 2 (NRF2), the master regulator of redox homeostasis. The severe …
erythroid 2-related factor 2 (NRF2), the master regulator of redox homeostasis. The severe …
The deubiquitinase USP29 promotes SARS-CoV-2 virulence by preventing proteasome degradation of ORF9b
Ubiquitin signaling is essential for immunity to restrict pathogen proliferation. Due to its
enormous impact on human health and the global economy, intensive efforts have been …
enormous impact on human health and the global economy, intensive efforts have been …
SARS-CoV-2 ORF10 suppresses the antiviral innate immune response by degrading MAVS through mitophagy
X Li, P Hou, W Ma, X Wang, H Wang, Z Yu… - Cellular & molecular …, 2022 - nature.com
The global coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused severe morbidity and …
respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused severe morbidity and …
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