The “serrated neoplastic pathway” describes the progression of serrated polyps, including
sessile serrated adenomas and traditional serrated adenomas, to colorectal cancer. The …

Until recently, two major forms of colorectal epithelial polyp were recognized: the adenoma
and the hyperplastic polyp. Adenomas were perceived to represent the precursor to …

Identification of the serrated neoplasia pathway has improved our understanding of the
pathogenesis of colorectal cancer (CRC). Insights include an increased recognition of the …

Colorectal cancer (CRC) is considered a heterogeneous disease, both regarding
pathogenesis and clinical behaviour. Four decades ago, the adenoma–carcinoma pathway …

Approximately 30% of colorectal carcinomas develop via the serrated neoplasia pathway
characterized by widespread DNA methylation and frequent BRAF mutation. Serrated …

In addition to the adenoma to carcinoma sequence, colorectal carcinogenesis can occur via
the serrated pathway. Studies have focused on clarification of categories and molecular …

Colorectal cancer (CRC) is a heterogeneous disorder than arises via multiple distinct
pathways, such as the serrated pathway, in which serrated polyps (including variants of …

The concept of serrated colorectal neoplasia and a serrated pathway to colorectal cancer
(CRC) is relatively new and continuing to evolve, but it has become highly relevant to …

Serrated adenocarcinoma is a recently described subset of colorectal cancer (CRC), which
account for about 10% of all CRCs and follows an alternative pathway in which serrated …

Advances in our understanding of the molecular basis of colorectal cancer (CRC) have shed
new light on the nature of hyperplastic polyps and invite a reassessment of the relevance of …