I In the last decade, the B-cell receptor has emerged as a pivotal stimulus in the
pathogenesis of chronic lymphocytic leukemia, and a very feasible therapeutic target in this …

The adapter protein SLP76 is a key orchestrator of T cell receptor (TCR) signal transduction.
We previously identified a negative feedback loop that modulates T cell activation, involving …

The SH2 domain-containing leukocyte adaptor protein of 65 kDa (SLP-65) is the key effector
for signaling downstream of the B-cell antigen receptor (BCR). SLP-65 controls not only B …

SLP76 and SLP65 are adaptor proteins that lack intrinsic enzymatic activity but contain
multiple protein-binding domains. These proteins are essential for signalling downstream of …

Despite the important role in the development and activation of T cells, NK cells, mast cells,
and macrophages, the expression and function of SLP‐76 in B cells have been largely …

SRC homology 2 domain-containing leukocyte phosphoprotein of 76 kDa (SLP-76) is a
cytosolic adaptor protein that plays an important role in the T-cell receptor–mediated T-cell …

SLP-76 (SH2 domain-containing leukocyte protein of 76 kDa) is an adaptor protein that is
essential for T cell development and T cell receptor (TCR) signaling activation. Previous …

A signaling pathway involving ZAP-70, LAT, and SLP76 has been regarded as essential for
receptor-driven T cell development and activation. Consistent with this model, mice deficient …

Chronic lymphocytic leukemia is a malignancy driven by abberant B cell signaling and
survival. Leukemic B cells accumulate in the peripheral blood and the lymphoid organs …

The SH2-domain-containing leukocyte protein of 76 kDa (SLP-76) plays a critical scaffolding
role in T cell receptor (TCR) signaling. As an adaptor protein that contains multiple protein …