Chloride channels represent a relatively under-explored target class for drug discovery as
elucidation of their identity and physiological roles has lagged behind that of many other …

Chloride channels are probably found in every cell, from bacteria to mammals. Their
physiological tasks range from cell volume regulation to stabilization of the membrane …

Cl− channels reside both in the plasma membrane and in intracellular organelles. Their
functions range from ion homeostasis to cell volume regulation, transepithelial transport, and …

Calcium-activated chloride channels (CaCCs) are widely expressed in mammalian tissues,
including intestinal epithelia, where they facilitate fluid secretion. Potent, selective CaCC …

▪ Abstract Calcium-activated chloride channels (CaCCs) play important roles in cellular
physiology, including epithelial secretion of electrolytes and water, sensory transduction …

Plasma membrane Cl− channels perform a variety of functions, including control of
excitability in neurons and muscle, cell volume regulation and transepithelial transport …

Until recently, anion (Cl−) channels have received considerably less attention than cation
channels. One reason for this may be that many Cl− channels perform functions that might …

Aim: This review describes molecular and functional properties of the following Cl–channels:
the ClC family of voltage‐dependent Cl–channels, the cAMP‐activated transmembrane …

Chloride channels are involved in a multitude of physiologic processes ranging from basal
cellular functions such as cell volume regulation and acidification of intracellular vesicles to …

Research into Ca 2+-activated Cl− channels is hampered by the inability to decipher their
molecular identity and the fact that all extant Cl− channel blockers have effects on other ion …