Purpose Chronic, abdominal pain remains a problem in a subset of patients after
cholecystectomy. The cause is often obscure but central sensitization may be an important …

Abstract Prostaglandin E2 (PGE2) is a lipid mediator which plays a role in the generation of
inflammatory and neuropathic pain. In the peripheral nervous system, PGE2 sensitizes …

It is widely accepted that prostaglandin (PG) E 2 is the principal pro-inflammatory prostanoid
and plays an important role in inflammatory pain. However whether PGE 2 is involved in …

Prostaglandin E2 (PGE2) plays a major role in pain processing and hypersensitivity. This
study investigated whether PGE2 levels are increased in the esophageal mucosa after acid …

Abstract Cyclooxygenase‐2 (COX‐2)‐dependent prostaglandin (PG) E2 synthesis in the
spinal cord plays a major role in the development of inflammatory hyperalgesia and …

IMPLICATIONS: Pain-related behavior and the cerebrospinal fluid (CSF) and tissue
prostaglandin E 2 (PGE 2) increase after surgery in rats can all be attenuated by …

Prostaglandin E2 (PGE2), a cyclooxygenase (COX) product, is the best known lipid mediator
that contributes to inflammatory pain. Nonsteroidal anti-inflammatory drugs (NSAIDs) …

Background Preoperative pain, type of operation and anesthesia, severity of acute
postoperative pain, and psychosocial factors have been identified as risk factors for chronic …

Neuropathic pain (NeP) is a common chronic pain state with unmet medical needs. Due to
poorly defined underlying mechanisms, current therapies for NeP are far from satisfactory …

Nonsteroidal anti‐inflammatory drugs (NSAIDs) alleviate inflammatory pain by inhibiting
prostanoid formation, but are associated with serious cardiovascular and gastrointestinal …