Gene expression is central to the genotype-phenotype relationship in all organisms, and it is
an important component of the genetic basis for evolutionary change in diverse aspects of …

Heritable variation in gene expression is common within and between species. This
variation arises from mutations that alter the form or function of molecular gene regulatory …

There is abundant variation in gene expression between individuals, populations, and
species. The evolution of gene regulation and expression within and between species is …

Eukaryotic transcriptional regulation requires the integration of complex signals by the
transcriptional promoter. Distinct sequence elements, characteristic chromatin modifications …

DNA is fundamentally important for all cellular organisms due to its role as a store of
hereditary genetic information. The precise and accurate regulation of gene transcription …

Although the evolution of protein-coding sequences within genomes is well understood, the
same cannot be said of the cis-regulatory regions that control transcription. Yet, changes in …

We recently witnessed a tremendous increase in genomics studies on gene regulation and
in entirely sequenced genomes from closely related species. This has triggered analyses …

The hypothesis that differences in gene regulation have an important role in speciation and
adaptation is more than 40 years old. With the advent of new sequencing technologies, we …

Surveys of gene expression reveal extensive variability both within and between a wide
range of species. Compelling cases have been made for adaptive changes in gene …

A long-standing question in evolutionary and developmental biology concerns the relative
contribution of cis-regulatory and protein changes to developmental evolution. Central to this …