[HTML][HTML] Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19 ARF
T Kamijo, F Zindy, MF Roussel, DE Quelle, JR Downing… - Cell, 1997 - cell.com
The INK4a tumor suppressor locus encodes p16 INK4a, an inhibitor of cyclin D-dependent
kinases, and p19 ARF, an alternative reading frame protein that also blocks cell proliferation …
kinases, and p19 ARF, an alternative reading frame protein that also blocks cell proliferation …
Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF
DE Quelle, M Cheng, RA Ashmun… - Proceedings of the …, 1997 - National Acad Sciences
The INK4a gene, one of the most frequently disrupted tumor suppressor loci in human
cancer, encodes two unrelated proteins, p16INK4a and p19ARF, each of which is capable of …
cancer, encodes two unrelated proteins, p16INK4a and p19ARF, each of which is capable of …
The INK4A/ARF locus: role in cell cycle control and apoptosis and implications for glioma growth
Abstract The unique INK4A/ARF locus at chromosome 9p21 encodes two distinct proteins
that intimately link the pRB and p53 tumour suppressor pathways. p16 INK4A has been …
that intimately link the pRB and p53 tumour suppressor pathways. p16 INK4A has been …
The differential impact of p16INK4a or p19ARF deficiency on cell growth and tumorigenesis
NE Sharpless, MR Ramsey, P Balasubramanian… - Oncogene, 2004 - nature.com
Mounting genetic evidence suggests that each product of the Ink4a/Arf locus, p16 INK4a and
p19 ARF, possesses tumor-suppressor activity (Kamijo et al., 1997; Krimpenfort et al., 2001; …
p19 ARF, possesses tumor-suppressor activity (Kamijo et al., 1997; Krimpenfort et al., 2001; …
The tumor-suppressive functions of the human INK4A locus
PM Voorhoeve, R Agami - Cancer cell, 2003 - cell.com
The INK4A locus is often inactivated in human cancer. INK4A encodes for p14 ARF and p16
INK4A that inhibit growth through p53 and pRb, respectively. We used RNA interference …
INK4A that inhibit growth through p53 and pRb, respectively. We used RNA interference …
[HTML][HTML] Role of the INK4a locus in tumor suppression and cell mortality
The cell cycle inhibitor p16 INK4a is inactivated in many human tumors and in families with
hereditary melanoma and pancreatic cancer. Tumor-associated alterations in the INK4a …
hereditary melanoma and pancreatic cancer. Tumor-associated alterations in the INK4a …
p16INK4A and p19ARF act in overlapping pathways in cellular immortalization
A Carnero, JD Hudson, CM Price, DH Beach - Nature cell biology, 2000 - nature.com
The INK4A locus encodes two independent but overlapping genes, p16 INK4A and p19
ARF, and is frequently inactivated in human cancers. The unusual structure of this locus has …
ARF, and is frequently inactivated in human cancers. The unusual structure of this locus has …
Absence of p16INK4a and truncation of ARF tumor suppressors in chickens
SH Kim, M Mitchell, H Fujii… - Proceedings of the …, 2003 - National Acad Sciences
The INK4b-ARF-INK4a locus on human chromosome 9p21 (Human Genome Organization
designation CDKN2B-CDKN2A), and the corresponding locus on mouse chromosome 4 …
designation CDKN2B-CDKN2A), and the corresponding locus on mouse chromosome 4 …
Tumor suppression by Ink4a–Arf: progress and puzzles
SW Lowe, CJ Sherr - Current opinion in genetics & development, 2003 - Elsevier
The two products of the Ink4a–Arf locus, p16Ink4a and p19Arf (p14ARF in humans), are
potent tumor suppressors that regulate the activities of the retinoblastoma protein and the …
potent tumor suppressors that regulate the activities of the retinoblastoma protein and the …
Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2
T Kamijo, JD Weber, G Zambetti… - Proceedings of the …, 1998 - National Acad Sciences
The INK4a-ARF locus encodes two proteins, p16INK4a and p19ARF, that restrain cell
growth by affecting the functions of the retinoblastoma protein and p53, respectively …
growth by affecting the functions of the retinoblastoma protein and p53, respectively …