Decades of cancer research have unraveled genetic, epigenetic and molecular pathways
leading to plausible therapeutic targets; many of which hold great promise in improving …

Metastasis means the dissemination of the cancer cells from one organ to another which is
not directly connected to the primary site. Metastasis has a crucial role in the prognosis of …

Many hypotheses have been postulated to explain the intricate nature of the metastatic
process, but none of them completely accounted for the actual biological and clinical …

Metastasis of malignant cells to vital organs remains the major cause of mortality in many
types of cancers. The tumour invasion–metastasis cascade is a stepwise and multistage …

Metastasis is the hallmark of cancer that is responsible for the greatest number of cancer-
related deaths. Yet, it remains poorly understood. The continuous evolution of cancer …

Cancer is the final result of uninhibited cell growth that involves an enormous group of
associated diseases. One major aspect of cancer is when cells attack adjacent components …

Cancer metastasis is responsible for the vast majority of cancer‐related deaths worldwide. In
contrast to numerous discoveries that reveal the detailed mechanisms leading to the …

Metastasis, the spread of malignant cells from a primary tumor to distant sites, poses the
biggest problem to cancer treatment and is the main cause of death of cancer patients. It …

Most cancer deaths are caused by metastasis rather than the primary tumor. Cancer cells
invade normal tissue as epithelial sheets or single cells by inducing expression of programs …

Background: The formation of distant metastases constitutes a complex process with a
variety of different genes and pathways involved. To improve patient survival, it is necessary …