The redox states of the NAD and NADP pyridine nucleotide pools play critical roles in
defining the activity of energy producing pathways, in driving oxidative stress and in …

More than 60 years ago, the idea was introduced that NADH autofluorescence could be
used as a marker of cellular redox state and indirectly also of cellular energy metabolism …

Reduced nicotinamide adenine dinucleotide, NADH, is a major electron donor in the
oxidative phosphorylation and glycolytic pathways in cells. As a result, there has been …

Nicotinamide adenine dinucleotide (NAD+/NADH) along with its phosphorylated form
(NADP+/NADPH) are two molecules ubiquitously present in all organisms, and they play key …

Significance: Optical imaging using the endogenous fluorescence of metabolic cofactors has
enabled nondestructive examination of dynamic changes in cell and tissue function both in …

Metabolism and mitochondrial dysfunction are known to be involved in many different
disease states. We have employed two-photon fluorescence imaging of intrinsic …

In the process of energy production, mitochondrial networks are key elements to allow
metabolism of substrates into ATP. Many pathological conditions have been associated with …

Mitochondria play a pivotal role in energy metabolism, programmed cell death and oxidative
stress. Mutated mitochondrial DNA in diseased cells compromises the structure of key …

NADH is a naturally fluorescent metabolite associated with cellular respiration. Exploiting
the different fluorescence lifetime of free and bound NADH has the potential to quantify the …

Normal mitochondrial function is a critical factor in maintaining cellular homeostasis in
various organs of the body. Due to the involvement of mitochondrial dysfunction in many …