The mammalian target of rapamycin (Mtor) gene encodes a serine/threonine kinase that acts
as a master regulator of processes as diverse as cell growth, protein synthesis, cytoskeleton …

Spermatogenesis is a continuous process, relying on the proliferation and differentiation of
spermatogonia. The mechanistic target of rapamycin complex 1 (mTORC1) is a central …

Spermatogonial stem cells must balance self-renewal with production of transit-amplifying
progenitors that differentiate in response to retinoic acid (RA) before entering meiosis. This …

STUDY QUESTION What is the physiological role of Rictor in spermatogenic cells?
SUMMARY ANSWER Germline expression of Rictor regulates spermatogonial …

Sertoli cells (SCs) play a central role in testis development, and their normal number and
functions are required for spermatogenesis. Although the canonical tuberous sclerosis …

Mammalian target of rapamycin (mTOR) is a central regulator of cellular metabolic
phenotype and is involved in virtually all aspects of cellular function. It integrates not only …

Spermatogonial stem cells (SSCs) must balance self-renewal with production of transit-
amplifying progenitors that differentiate in response to retinoic acid (RA) before entering …

Abstract mTOR (mammalian target of rapamycin) is one of the most important signaling
molecules in mammalian cells which regulates an array of cellular events, ranging from cell …

The self-renewal, proliferation, and differentiation of the spermatogonial populations must be
finely coordinated in the mammalian testis, as dysregulation of these processes can lead to …

Male fertility is modulated by environmental, endocrine, paracrine, and metabolic cues.
Mammalian target of rapamycin (mTOR) coordinates many cellular events in response to …