[HTML][HTML] De novo endocytic clathrin coats develop curvature at early stages of their formation

NM Willy, JP Ferguson, A Akatay, S Huber… - Developmental cell, 2021 - cell.com
Sculpting a flat patch of membrane into an endocytic vesicle requires curvature generation
on the cell surface, which is the primary function of the endocytosis machinery. Using super …

[HTML][HTML] The structure and spontaneous curvature of clathrin lattices at the plasma membrane

KA Sochacki, BL Heine, GJ Haber, JR Jimah… - Developmental Cell, 2021 - cell.com
Clathrin-mediated endocytosis is the primary pathway for receptor and cargo internalization
in eukaryotic cells. It is characterized by a polyhedral clathrin lattice that coats budding …

[HTML][HTML] Clathrin-adaptor ratio and membrane tension regulate the flat-to-curved transition of the clathrin coat during endocytosis

D Bucher, F Frey, KA Sochacki, S Kummer… - Nature …, 2018 - nature.com
Although essential for many cellular processes, the sequence of structural and molecular
events during clathrin-mediated endocytosis remains elusive. While it was long believed that …

Clathrin coats partially preassemble and subsequently bend during endocytosis

M Mund, A Tschanz, YL Wu, F Frey, JL Mehl… - Journal of Cell …, 2023 - rupress.org
Eukaryotic cells use clathrin-mediated endocytosis to take up a large range of extracellular
cargo. During endocytosis, a clathrin coat forms on the plasma membrane, but it remains …

Superresolution microscopy reveals partial preassembly and subsequent bending of the clathrin coat during endocytosis

M Mund, A Tschanz, YL Wu, F Frey, JL Mehl… - BioRxiv, 2021 - biorxiv.org
Eukaryotic cells use clathrin-mediated endocytosis to take up a large range of extracellular
cargos. During endocytosis, a clathrin coat forms on the plasma membrane, but it remains …

Evolving models for assembling and shaping clathrin-coated pits

Z Chen, SL Schmid - Journal of Cell Biology, 2020 - rupress.org
Clathrin-mediated endocytosis occurs via the assembly of clathrin-coated pits (CCPs) that
invaginate and pinch off to form clathrin-coated vesicles (CCVs). It is well known that adaptor …

[HTML][HTML] CALM regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature

SE Miller, S Mathiasen, NA Bright, F Pierre, BT Kelly… - Developmental cell, 2015 - cell.com
The size of endocytic clathrin-coated vesicles (CCVs) is remarkably uniform, suggesting that
it is optimized to achieve the appropriate levels of cargo and lipid internalization. The three …

Flat clathrin lattices: stable features of the plasma membrane

J Grove, DJ Metcalf, AE Knight… - Molecular biology of …, 2014 - Am Soc Cell Biol
Clathrin-mediated endocytosis (CME) is a fundamental property of eukaryotic cells.
Classical CME proceeds via the formation of clathrin-coated pits (CCPs) at the plasma …

[HTML][HTML] Membrane bending occurs at all stages of clathrin-coat assembly and defines endocytic dynamics

BL Scott, KA Sochacki, ST Low-Nam, EM Bailey… - Nature …, 2018 - nature.com
Clathrin-mediated endocytosis (CME) internalizes plasma membrane by reshaping small
regions of the cell surface into spherical vesicles. The key mechanistic question of how coat …

Distinct dynamics of endocytic clathrin coated pits and coated plaques

S Saffarian, T Kirchhausen - Biophysical Journal, 2009 - cell.com
Wednesday, March 4, 2009 569a that deform the underlying membrane by progressive
recruitment of clathrin, adaptors and other regulatory proteins. They ultimately close off and …