Sculpting a flat patch of membrane into an endocytic vesicle requires curvature generation
on the cell surface, which is the primary function of the endocytosis machinery. Using super …

Clathrin-mediated endocytosis is the primary pathway for receptor and cargo internalization
in eukaryotic cells. It is characterized by a polyhedral clathrin lattice that coats budding …

Although essential for many cellular processes, the sequence of structural and molecular
events during clathrin-mediated endocytosis remains elusive. While it was long believed that …

Eukaryotic cells use clathrin-mediated endocytosis to take up a large range of extracellular
cargo. During endocytosis, a clathrin coat forms on the plasma membrane, but it remains …

Eukaryotic cells use clathrin-mediated endocytosis to take up a large range of extracellular
cargos. During endocytosis, a clathrin coat forms on the plasma membrane, but it remains …

Clathrin-mediated endocytosis occurs via the assembly of clathrin-coated pits (CCPs) that
invaginate and pinch off to form clathrin-coated vesicles (CCVs). It is well known that adaptor …

The size of endocytic clathrin-coated vesicles (CCVs) is remarkably uniform, suggesting that
it is optimized to achieve the appropriate levels of cargo and lipid internalization. The three …

Clathrin-mediated endocytosis (CME) is a fundamental property of eukaryotic cells.
Classical CME proceeds via the formation of clathrin-coated pits (CCPs) at the plasma …

Clathrin-mediated endocytosis (CME) internalizes plasma membrane by reshaping small
regions of the cell surface into spherical vesicles. The key mechanistic question of how coat …

Wednesday, March 4, 2009 569a that deform the underlying membrane by progressive
recruitment of clathrin, adaptors and other regulatory proteins. They ultimately close off and …