A series of macrocyclic pyrido-pentapeptide candidates 2–6 were synthesized by using N, N-
bis-[1-carboxy-2-(benzyl)]-2, 6-(diaminocarbonyl) pyridine 1a, b as starting material …

Cancer is a multifactorial disorder with extremely complex genetics and progression. The
major challenge in cancer therapy is the development of cancer resistance and relapse …

Under-expression or overexpression of protein kinases has been shown to be associated
with unregulated cell signal transduction in cancer cells. Therefore, there is major interest in …

An efficient synthesis of substituted pyrido [2, 3-d] pyrimidines was carried out and evaluated
for in vitro anticancer activity against five cancer cell lines, namely hepatic cancer (HepG-2) …

Aiming to obtain an efficient anti-proliferative activity, structure-and ligand-based drug
design approaches were expanded and utilized to design and refine a small compound …

Protein kinases (PKs) represent one of the most important targets in the discovery of new
drug candidates in oncology based on their crucial roles in the processes of cellular growth …

Staurosporine, pyridone 6 and hydroxyfasudil are cyclic amide (pyridone/lactam) moiety
containing heterocycles that are discovered/developed as potent protein kinase inhibitors …

A novel series of pyridin-3-amine derivatives were designed, synthesized, and evaluated as
multitargeted protein kinase inhibitors for the treatment of non-small cell lung cancer …

A new series of N-substituted-2-aminopyrimidines based on the '4-(pyridin-3-yl) pyrimidin-2-
amine'scaffold of Imatinib has been designed and synthesized. A selected group from the …

In the last twenty years, protein kinases have been identified as important targets for cancer
therapy. In order to prevent unexpected toxicity, medicinal chemists have always focused on …