During vertebrate axis extension, adjacent tissue layers undergo profound morphological
changes: within the neuroepithelium, neural tube closure and neural crest formation are …

In vertebrate early development, the neural tissue is specified along the antero-posterior
(AP) axis by the activity of graded patterning signals such as Wnt, Nodal and FGF …

During early embryogenesis, FGF signals regulate the antero-posterior (AP) patterning of
the neural plate by promoting posterior cell fates. In particular, BMP signal-mediated …

CNS stem cells are best characterized by their ability to self-renew and to generate multiple
differentiated derivatives, but the effect of mitogenic signals, such as fibroblast growth factor …

Abstract Bone Morphogenetic Protein (BMP) activity has been implicated as a key regulator
of multiple aspects of dorsal neural tube development. BMP signaling in the dorsal‐most …

During amphibian development, neural patterning occurs via a two‐step process.
Spemann's organizer secretes BMP antagonists that induce anterior neural tissue. A …

Cranial neural crest cells (CNCCs) have the remarkable capacity to generate both the non-
ectomesenchyme derivatives of the peripheral nervous system and the ectomesenchyme …

Vertebrate body axis extension involves progressive generation and subsequent
differentiation of new cells derived from a caudal stem zone; however, molecular …

BACKGROUND A critical event in neural tube closure is the formation of median hinge
points (MHPs) and dorsolateral hinge points (DLHPs). Together, they buckle the ventral …

During neural tube closure, specialized regions called hinge points (HPs) display dynamic
and polarized cell behaviors necessary for converting the neural plate into a neural tube …