Background The spread of antibiotic-resistant bacteria poses a substantial threat to
morbidity and mortality worldwide. Due to its large public health and societal implications …

This analysis of the global clinical antibacterial pipeline was done in support of the Global
Action Plan on Antimicrobial Resistance. The study analysed to what extent antibacterial …

Antimicrobial resistance is threatening the management of infections such as pneumonia,
tuberculosis, malaria, and AIDS. In the past, resistance could be handled by development of …

Summary Each year, an estimated 7· 7 million deaths are attributed to bacterial infections, of
which 4.95 million are associated with drug-resistant pathogens, and 1· 27 million are …

The increasing number of bacterial infections globally that do not respond to any available
antibiotics indicates a need to invest in—and ensure access to—new antibiotics, vaccines …

In 1945, Sir Alexander Fleming famously warned of the danger of over-reliance on
antibiotics and the threat of bacteria developing resistance. 1 68 years later, his prediction …

Antibiotic use not only underpins modern medicine, but has brought huge changes to the
world, especially in expectations of survival of children into adulthood. The theme of World …

The emergence and spread of antimicrobial-resistant bacterial, viral, and fungal pathogens
for which diminishing treatment options are available is of major global concern. New viral …

The time has come for a global commitment to develop new antibacterial drugs. Current data
document the impending disaster due to the confluence of decreasing investment in …

Antibiotics have saved countless lives and enabled the development of modern medicine
over the past 70 years. However, it is clear that the success of antibiotics might only have …