Members of the seven-transmembrane receptor (7TMR), or G protein-coupled receptor
(GPCR), superfamily represent some of the most successful targets of modern drug therapy …

Seven-transmembrane receptors (7TMRs), the most common molecular targets of modern
drug therapy, are critically regulated by β-arrestins, which both inhibit classic G-protein …

Abstract Seven-transmembrane receptors (7TMRs; also known as G protein-coupled
receptors) are the largest class of receptors in the human genome and are common targets …

G‐protein‐coupled receptors (GPCRs), also known as seven transmembrane receptors (7‐
TMRs), are the largest protein receptor superfamily in the body. These receptors and their …

β-Arrestins, originally discovered to desensitize activated seven transmembrane receptors
(7TMRs; also known as G-protein-coupled receptors, GPCRs), are now well established …

The concept of biased agonism has recently come to the fore with the realization that seven-
transmembrane receptors (7TMRs, also known as G protein–coupled receptors, or GPCRs) …

β-arrestins critically regulate G protein-coupled receptors (GPCRs), also known as seven-
transmembrane receptors (7TMRs), both by inhibiting classical G protein signaling and by …

β-Arrestins function as endocytic adaptors and mediate trafficking of a variety of cell-surface
receptors, including seven-transmembrane receptors (7TMRs). In the case of 7TMRs, β …

Cell surface receptors are important communicators of external stimuli to the cell interior
where they lead to initiation of various signaling pathways and cellular responses. The …

G protein-coupled receptor-targeted drug discovery as well as “compound reassessment”
requires the utilization of diverse screens to determine agonist efficacies and potencies …