Regenerative approaches for the treatment of large bone defects

A Stahl, YP Yang - Tissue Engineering Part B: Reviews, 2021 - liebertpub.com
A variety of engineered materials have gained acceptance in orthopedic practice as
substitutes for autologous bone grafts, although the regenerative efficacy of these …

Evolution of bone grafting: bone grafts and tissue engineering strategies for vascularized bone regeneration

KS Griffin, KM Davis, TO McKinley, JO Anglen… - Clinical reviews in bone …, 2015 - Springer
The regeneration of bone in segmental defects has historically been a challenge in the
orthopedic field. In particular, a lack of vascular supply often leads to nonunion and …

Vascularization in bone tissue engineering constructs

ÁE Mercado-Pagán, AM Stahl, Y Shanjani… - Annals of biomedical …, 2015 - Springer
Vascularization of large bone grafts is one of the main challenges of bone tissue
engineering (BTE), and has held back the clinical translation of engineered bone constructs …

Vascularized bone tissue engineering: approaches for potential improvement

LH Nguyen, N Annabi, M Nikkhah, H Bae… - … Engineering Part B …, 2012 - liebertpub.com
Significant advances have been made in bone tissue engineering (TE) in the past decade.
However, classical bone TE strategies have been hampered mainly due to the lack of …

Tissue engineering approaches for bone repair: concepts and evidence

JE Schroeder, R Mosheiff - Injury, 2011 - Elsevier
Over the last decades, the medical world has advanced dramatically in the understanding of
fracture repair. The three components needed for fracture healing are osteoconduction …

[HTML][HTML] Synthetic and Bone tissue engineering graft substitutes: What is the future?

RS Valtanen, YP Yang, GC Gurtner, WJ Maloney… - Injury, 2021 - Elsevier
The management of large segmental bone defects caused by trauma or disease remains
clinically challenging within orthopaedics. The major impediment to bone healing with …

Skeletal regeneration for segmental bone loss: vascularised grafts, analogues and surrogates

B Dalisson, B Charbonnier, A Aoude, M Gilardino… - Acta Biomaterialia, 2021 - Elsevier
Massive segmental bone defects (SBD) are mostly treated by removing the fibula and
transplanting it complete with blood supply. While revolutionary 50 years ago, this remains …

Review of vascularised bone tissue‐engineering strategies with a focus on co‐culture systems

Y Liu, JKY Chan, SH Teoh - Journal of tissue engineering and …, 2015 - Wiley Online Library
Poor angiogenesis within tissue‐engineered grafts has been identified as a main challenge
limiting the clinical introduction of bone tissue‐engineering (BTE) approaches for the repair …

Bone regenerative medicine: classic options, novel strategies, and future directions

A Oryan, S Alidadi, A Moshiri, N Maffulli - Journal of orthopaedic surgery …, 2014 - Springer
This review analyzes the literature of bone grafts and introduces tissue engineering as a
strategy in this field of orthopedic surgery. We evaluated articles concerning bone grafts; …

Biomaterial-mediated strategies targeting vascularization for bone repair

JR García, AJ García - Drug delivery and translational research, 2016 - Springer
Repair of non-healing bone defects through tissue engineering strategies remains a
challenging feat in the clinic due to the aversive microenvironment surrounding the injured …