Increasing evidence supports the rapid antidepressant effect of a low-dose ketamine
infusion in treatment-resistant depression (TRD). Proinflammatory cytokines play a crucial …

Increasing evidence has demonstrated that inflammatory cytokines play an important role in
major depressive disorder (MDD) and are associated with treatment outcomes. Few studies …

Several pro-inflammatory cytokines have been implicated in depression and in
antidepressant response. This exploratory analysis assessed: 1) the extent to which …

Background Ketamine is reported to have rapid antidepressant effects; however, there is
limited understanding of the time-course of ketamine effects beyond a single infusion. A …

Objectives We examined the feasibility of a high-dose, 96-h infusion of ketamine in treatment-
resistant depression. Methods Ten participants were randomised to receive a 96-h ketamine …

Background Treatment-resistant depression (TRD) and pain frequently coexist clinically.
Ketamine has analgesic and antidepressant effects, but few studies have evaluated …

Background Clinical and animal studies have reported conflicting results regarding the effect
of ketamine on cognitive function, although increasing evidence supports a rapid and …

In this review, we will discuss the safety of repeated treatments with ketamine for patients
with treatment-resistant depression (TRD), a condition in which patients with major …

Background Sub-anaesthetic administration of ketamine is an emerging practice in patients
presenting treatment resistant depression (TRD), however several outstanding questions …

Background Major depressive disorder (MDD) exerts a high health and financial burden on
society. The conventional pharmacotherapies for MDD are partially effective and the …