Syzygium aromaticum Extracts as a Potential Antibacterial Inhibitors against Clinical Isolates of Acinetobacter baumannii: An In-Silico-Supported In-Vitro Study

A Mahmoud, MM Afifi, F El Shenawy, W Salem… - Antibiotics, 2021 - mdpi.com
Imipenem is the most efficient antibiotic against Acinetobacter baumannii infection, but new
research has shown that the organism has also developed resistance to this agent. A …

In silico and in vitro studies of a number PILs as new antibacterials against MDR clinical isolate Acinetobacter baumannii

MM Trush, V Kovalishyn, D Hodyna… - Chemical Biology & …, 2020 - Wiley Online Library
QSAR analysis of a set of previously synthesized phosphonium ionic liquids (PILs) tested
against Gram‐negative multidrug‐resistant clinical isolate Acinetobacter baumannii was …

Identification of putative non-host essential genes and novel drug targets against Acinetobacter baumannii by in silico comparative genome analysis

R Uddin, F Masood, SS Azam, A Wadood - Microbial pathogenesis, 2019 - Elsevier
Acinetobacter baumannii, the gram-negative bacteria emerged as an extremely critical
pathogen causing nosocomial and different kinds of infections. A. baumannii exhibit …

Investigating the antibacterial mechanism of Ampelopsis cantoniensis extracts against methicillin-resistant Staphylococcus aureus via in vitro and in silico analysis

VNT Bich, TK Nguyen, TDT Thu, LTT Tran… - Journal of …, 2023 - Taylor & Francis
Methicillin-resistant Staphylococcus aureus (MRSA) is a critical pathogen responsible for a
wide variety of serious infectious diseases in humans. The accelerated phenomena of drug …

Integrated computer-aided drug design and biophysical simulation approaches to determine natural anti-bacterial compounds for Acinetobacter baumannii

RAH Almihyawi, ZT Naman, HMH Al-Hasani… - Scientific reports, 2022 - nature.com
Acinetobacter baumannii is a nosocomial bacterial pathogen and is responsible for a wide
range of diseases including pneumonia, necrotizing fasciitis, meningitis, and sepsis. The …

In Silico Method for the Screening of Phytochemicals against Methicillin‐Resistant Staphylococcus Aureus

R Tabassum, S Kousar, G Mustafa… - BioMed Research …, 2023 - Wiley Online Library
Methicillin‐resistant Staphylococcus aureus (MRSA) has evolved resistance even against
the last resort β‐lactam antibiotics. This is because of the acquisition of an additional …

In silico exploration of phenolics as modulators of penicillin binding protein (PBP) 2× of Streptococcus pneumoniae

JO Aribisala, NW S'thebe, S Sabiu - Scientific Reports, 2024 - nature.com
Infections caused by multidrug-resistant Streptococcus pneumoniae remain the leading
cause of pneumonia-related deaths in children< 5 years globally, and mutations in penicillin …

Anti-Acinetobacter baumannii activity of selected phytochemicals alone, in binary combinations and in combinations with conventional antibiotics

V Aleksic Sabo, I Nikolic, N Mimica-Dukic… - Natural Product …, 2021 - Taylor & Francis
Acinetobacter baumannii is one of the emerging multidrug-and pandrug-resistant
pathogens. The aim of the study was to determine anti-A. baumannii activity of selected …

In Silico Evaluation of Bioactive Compounds of Artemisia pallens Targeting the Efflux Protein of Multidrug-Resistant Acinetobacter baumannii (LAC-4 Strain)

S Suvaithenamudhan, S Ananth, V Mariappan… - Molecules, 2022 - mdpi.com
Acinetobacter baumannii (A. baumannii) is one of the major representative aetiologies of
recalcitrant nosocomial infections. Genotypic and phenotypic alterations in A. baumannii …

Structure-activity relationship-based screening of antibiotics against Gram-negative Acinetobacter baumannii

JY Lee, MC Jeong, D Jeon, Y Lee, WC Lee… - Bioorganic & Medicinal …, 2017 - Elsevier
To discover potent antibiotics against the Gram-negative bacteria, we performed a structure-
activity relationship (SAR) study of YKsa-6, which was the most potent inhibitor of …