Synthesis of novel azo compounds containing 5 (4H)-oxazolone ring as potent tyrosinase inhibitors

H Hamidian, R Tagizadeh, S Fozooni… - Bioorganic & medicinal …, 2013 - Elsevier
Six new azo dyes containing of 5 (4H)-oxazolone ring were prepared by diazotization of 4-
aminohippuric acid and coupling with N, N-dimethylaniline, 1-naphthol and 2-naphthol and …

Synthesis of novel compounds as new potent tyrosinase inhibitors

H Hamidian - BioMed Research International, 2013 - Wiley Online Library
In the present paper, we report the synthesis and pharmacological evaluation of a new
series of azo compounds with different groups (1‐naphthol, 2‐naphthol, and N, N …

Synthesis of novel compounds containing morpholine and 5 (4H)-oxazolone rings as potent tyrosinase inhibitors

H Hamidian, S Azizi - Bioorganic & Medicinal Chemistry, 2015 - Elsevier
In this study, six new compounds containing morpholine and 5 (4 H)-oxazolone rings were
synthesized. Structures of the new compounds using IR, 1 H NMR, mass spectroscopy and …

Synthesis of novel azo-resveratrol, azo-oxyresveratrol and their derivatives as potent tyrosinase inhibitors

YM Song, YM Ha, JA Kim, KW Chung, Y Uehara… - Bioorganic & medicinal …, 2012 - Elsevier
Ten azo compounds including azo-resveratrol (5) and azo-oxyresveratrol (9) were
synthesized using a modified Curtius rearrangement and diazotization followed by coupling …

Evaluation of thiazolidinone derivatives as a new class of mushroom tyrosinase inhibitors

M Rezaei, HT Mohammadi, A Mahdavi… - International journal of …, 2018 - Elsevier
Abstract Tyrosinase (EC 1.14. 18.1) is a key copper-containing metalloenzyme widely
distributed in nature and plays determinant role in melanin biosynthesis. The enzyme …

Synthesis and biological evaluation of kojic acid derivatives containing 1, 2, 4‐triazole as potent tyrosinase inhibitors

W Xie, J Zhang, X Ma, W Yang, Y Zhou… - Chemical Biology & …, 2015 - Wiley Online Library
A series of 5‐substituted‐3‐[5‐hydroxy‐4‐pyrone‐2‐yl‐methymercapto]‐4‐amino‐1, 2, 4‐
triazole derivatives were synthesized by nucleophilic substitution reaction of 5‐hydroxy‐2 …

A novel synthesized tyrosinase inhibitor:(E)-2-((2, 4-dihydroxyphenyl) diazenyl) phenyl 4-methylbenzenesulfonate as an azo-resveratrol analog

SJ Bae, YM Ha, JA Kim, JY Park, TK Ha… - Bioscience …, 2013 - jstage.jst.go.jp
We synthesized a novel series of (E)-2-((substituted phenyl) diazenyl) phenyl 4-
methylbenzenesulfonate derivatives (2 and 3) and (E)-2-((substituted phenyl) diazenyl) …

Synthesis and biological evaluation of novel hydroxybenzaldehyde-based kojic acid analogues as inhibitors of mushroom tyrosinase

W Xie, H Zhang, J He, J Zhang, Q Yu, C Luo… - Bioorganic & Medicinal …, 2017 - Elsevier
Two series of novel kojic acid analogues (4a–j) and (5a–d) were designed and synthesized,
and their mushroom tyrosinase inhibitory activities was evaluated. The result indicated that …

Design and synthesis of 3, 5-diaryl-4, 5-dihydro-1H-pyrazoles as new tyrosinase inhibitors

Z Zhou, J Zhuo, S Yan, L Ma - Bioorganic & medicinal chemistry, 2013 - Elsevier
In this study, twenty 3, 5-diaryl-4, 5-dihydro-1H-pyrazole derivatives with hydroxyl (s)(1a–1p,
2a–2d) were synthesized and their inhibitory activity on mushroom tyrosinase was …

Design and synthesis of 5-(substituted benzylidene) thiazolidine-2, 4-dione derivatives as novel tyrosinase inhibitors

YM Ha, YJ Park, JA Kim, D Park, JY Park… - European journal of …, 2012 - Elsevier
In continuing our search for novel tyrosinase inhibitors, a series of 5-(substituted
benzylidene) thiazolidine-2, 4-diones were rationally designed and synthesized, and their …