[PDF][PDF] Riboflavin Functionalized Nanocarriers for Active Targeting of Cancer Cells

M Dargužytė - 2022 - publications.rwth-aachen.de
Cancer remains the number one cause of death worldwide (Bray et al. 2021). In 2020 almost
10 million people died due to cancer (Sung et al. 2021). Current treatment options include …

[PDF][PDF] Riboflavin-targeted nanomedicines for cancer imaging and drug delivery

Y Tsvetkova - 2018 - d-nb.info
Molecular imaging is a medical field which deals with the visualization of biological
conditions and processes in a living organism. Such conditions and processes include …

Balancing passive and active targeting to different tumor compartments using riboflavin-functionalized polymeric nanocarriers

Y Tsvetkova, N Beztsinna, M Baues, D Klein, A Rix… - Nano …, 2017 - ACS Publications
Riboflavin transporters (RFTs) and the riboflavin carrier protein (RCP) are highly
upregulated in many tumor cells, tumor stem cells, and tumor neovasculature, which makes …

Riboflavin-targeted drug delivery

M Darguzyte, N Drude, T Lammers, F Kiessling - Cancers, 2020 - mdpi.com
Active targeting can improve the retention of drugs and drug delivery systems in tumors,
thereby enhancing their therapeutic efficacy. In this context, vitamin receptors that are …

Amphiphilic phospholipid-based riboflavin derivatives for tumor targeting nanomedicines

N Beztsinna, Y Tsvetkova, M Bartneck… - Bioconjugate …, 2016 - ACS Publications
Riboflavin (RF) is an essential vitamin for cellular metabolism. Recent studies have shown
that RF is internalized through RF transporters, which are highly overexpressed by prostate …

In vivo evaluation of riboflavin receptor targeted fluorescent USPIO in mice with prostate cancer xenografts

J Jayapaul, S Arns, M Bunker, M Weiler, S Rutherford… - Nano Research, 2016 - Springer
Riboflavin (Rf) receptors bind and translocate Rf and its phosphorylated forms (eg flavin
mononucleotide, FMN) into cells where they mediate various cellular metabolic pathways …

FMN-coated fluorescent iron oxide nanoparticles for RCP-mediated targeting and labeling of metabolically active cancer and endothelial cells

J Jayapaul, M Hodenius, S Arns, W Lederle… - Biomaterials, 2011 - Elsevier
Riboflavin is an essential vitamin for cellular metabolism and is highly upregulated in
metabolically active cells. Consequently, targeting the riboflavin carrier protein (RCP) may …

Riboflavin-based amphiphiles for tumour-targeted nanosystems

NS Beztsinna - 2015 - theses.hal.science
Riboflavin (RF) is an essential vitamin for cell growth and development. It possesses
interesting physicochemical properties and is internalized by the cells through specific …

Supramolecular host–guest chemistry-based folate/riboflavin functionalization and cancer cell labeling of nanoparticles

S Pal, C Dalal, NR Jana - ACS omega, 2017 - ACS Publications
Nanoparticle-based cellular probes are commonly designed via covalent conjugation with
affinity biomolecules. Those nanobioconjugates selectively interact with cell surface …

Novel Nano Cargoes as Chemotherapeutic Agents

K Agrawal, A Gupta, S Saraf - Pharmaceutical …, 2023 - pharmabiosciencejournal.com
Because conventional chemotherapy for cancer does not specifically select cells only that
are tumor, it is limited in its ability to cure cancer, so is easily associated with harmful and …