Pitfalls of predicting complex traits from SNPs

NR Wray, J Yang, BJ Hayes, AL Price… - Nature Reviews …, 2013 - nature.com
The success of genome-wide association studies (GWASs) has led to increasing interest in
making predictions of complex trait phenotypes, including disease, from genotype data …

Genetics of complex traits: prediction of phenotype, identification of causal polymorphisms and genetic architecture

ME Goddard, KE Kemper… - … of the Royal …, 2016 - royalsocietypublishing.org
Complex or quantitative traits are important in medicine, agriculture and evolution, yet, until
recently, few of the polymorphisms that cause variation in these traits were known. Genome …

[HTML][HTML] Leveraging functional genomic annotations and genome coverage to improve polygenic prediction of complex traits within and between ancestries

Z Zheng, S Liu, J Sidorenko, Y Wang, T Lin, L Yengo… - Nature Genetics, 2024 - nature.com
We develop a method, SBayesRC, that integrates genome-wide association study (GWAS)
summary statistics with functional genomic annotations to improve polygenic prediction of …

[图书][B] Genome-wide association studies and genomic prediction

C Gondro, J Van der Werf, B Hayes - 2013 - Springer
Genome-wide association studies (GWAS) have rapidly spread across the globe over the
last few years becoming the de facto approach to identify candidate regions associated with …

[HTML][HTML] MultiPhen: joint model of multiple phenotypes can increase discovery in GWAS

PF O'Reilly, CJ Hoggart, Y Pomyen, FCF Calboli… - PloS one, 2012 - journals.plos.org
The genome-wide association study (GWAS) approach has discovered hundreds of genetic
variants associated with diseases and quantitative traits. However, despite clinical overlap …

Risk prediction using genome‐wide association studies

C Kooperberg, M LeBlanc… - Genetic epidemiology, 2010 - Wiley Online Library
Over the last few years, many new genetic associations have been identified by genome‐
wide association studies (GWAS). There are potentially many uses of these identified …

[HTML][HTML] Underestimated effect sizes in GWAS: fundamental limitations of single SNP analysis for dichotomous phenotypes

S Stringer, NR Wray, RS Kahn, EM Derks - PloS one, 2011 - journals.plos.org
Complex diseases are often highly heritable. However, for many complex traits only a small
proportion of the heritability can be explained by observed genetic variants in traditional …

Mining the unknown: assigning function to noncoding single nucleotide polymorphisms

SS Nishizaki, AP Boyle - Trends in Genetics, 2017 - cell.com
One of the formative goals of genetics research is to understand how genetic variation leads
to phenotypic differences and human disease. Genome-wide association studies (GWASs) …

Beyond odds ratios—communicating disease risk based on genetic profiles

P Kraft, S Wacholder, MC Cornelis, FB Hu… - Nature Reviews …, 2009 - nature.com
The brisk discovery of novel inherited disease markers by genome-wide association (GWA)
studies has raised expectations for predicting disease risk by analysing multiple common …

[HTML][HTML] Predicting unobserved phenotypes for complex traits from whole-genome SNP data

SH Lee, JHJ Van Der Werf, BJ Hayes… - PLoS …, 2008 - journals.plos.org
Genome-wide association studies (GWAS) for quantitative traits and disease in humans and
other species have shown that there are many loci that contribute to the observed …