Pitfalls of predicting complex traits from SNPs
The success of genome-wide association studies (GWASs) has led to increasing interest in
making predictions of complex trait phenotypes, including disease, from genotype data …
making predictions of complex trait phenotypes, including disease, from genotype data …
Genetics of complex traits: prediction of phenotype, identification of causal polymorphisms and genetic architecture
ME Goddard, KE Kemper… - … of the Royal …, 2016 - royalsocietypublishing.org
Complex or quantitative traits are important in medicine, agriculture and evolution, yet, until
recently, few of the polymorphisms that cause variation in these traits were known. Genome …
recently, few of the polymorphisms that cause variation in these traits were known. Genome …
[HTML][HTML] Leveraging functional genomic annotations and genome coverage to improve polygenic prediction of complex traits within and between ancestries
We develop a method, SBayesRC, that integrates genome-wide association study (GWAS)
summary statistics with functional genomic annotations to improve polygenic prediction of …
summary statistics with functional genomic annotations to improve polygenic prediction of …
[图书][B] Genome-wide association studies and genomic prediction
C Gondro, J Van der Werf, B Hayes - 2013 - Springer
Genome-wide association studies (GWAS) have rapidly spread across the globe over the
last few years becoming the de facto approach to identify candidate regions associated with …
last few years becoming the de facto approach to identify candidate regions associated with …
[HTML][HTML] MultiPhen: joint model of multiple phenotypes can increase discovery in GWAS
The genome-wide association study (GWAS) approach has discovered hundreds of genetic
variants associated with diseases and quantitative traits. However, despite clinical overlap …
variants associated with diseases and quantitative traits. However, despite clinical overlap …
Risk prediction using genome‐wide association studies
C Kooperberg, M LeBlanc… - Genetic epidemiology, 2010 - Wiley Online Library
Over the last few years, many new genetic associations have been identified by genome‐
wide association studies (GWAS). There are potentially many uses of these identified …
wide association studies (GWAS). There are potentially many uses of these identified …
[HTML][HTML] Underestimated effect sizes in GWAS: fundamental limitations of single SNP analysis for dichotomous phenotypes
Complex diseases are often highly heritable. However, for many complex traits only a small
proportion of the heritability can be explained by observed genetic variants in traditional …
proportion of the heritability can be explained by observed genetic variants in traditional …
Mining the unknown: assigning function to noncoding single nucleotide polymorphisms
SS Nishizaki, AP Boyle - Trends in Genetics, 2017 - cell.com
One of the formative goals of genetics research is to understand how genetic variation leads
to phenotypic differences and human disease. Genome-wide association studies (GWASs) …
to phenotypic differences and human disease. Genome-wide association studies (GWASs) …
Beyond odds ratios—communicating disease risk based on genetic profiles
The brisk discovery of novel inherited disease markers by genome-wide association (GWA)
studies has raised expectations for predicting disease risk by analysing multiple common …
studies has raised expectations for predicting disease risk by analysing multiple common …
[HTML][HTML] Predicting unobserved phenotypes for complex traits from whole-genome SNP data
Genome-wide association studies (GWAS) for quantitative traits and disease in humans and
other species have shown that there are many loci that contribute to the observed …
other species have shown that there are many loci that contribute to the observed …