Mechanisms of hair cell damage and repair

EL Wagner, JB Shin - Trends in neurosciences, 2019 - cell.com
Sensory hair cells of the inner ear are exposed to continuous mechanical stress, causing
damage over time. The maintenance of hair cells is further challenged by damage from a …

The challenge of hair cell regeneration

AK Groves - Experimental Biology and Medicine, 2010 - journals.sagepub.com
Sensory hair cells of the inner ear are responsible for translating auditory or vestibular
stimuli into electrical energy that can be perceived by the nervous system. Although hair …

Hair cell regeneration

Y Chen, S Zhang, R Chai, H Li - Hearing loss: Mechanisms, prevention …, 2019 - Springer
Cochlear hair cells are mechanoreceptors of the auditory system and cannot spontaneously
regenerate in adult mammals; thus hearing loss due to hair cell damage is permanent. In …

Sensory hair cell death and regeneration in fishes

JD Monroe, G Rajadinakaran, ME Smith - Frontiers in cellular …, 2015 - frontiersin.org
Sensory hair cells are specialized mechanotransductive receptors required for hearing and
vestibular function. Loss of hair cells in humans and other mammals is permanent and …

Chemical screening for hair cell loss and protection in the zebrafish lateral line

AB Coffin, H Ou, KN Owens, F Santos, JA Simon… - Zebrafish, 2010 - liebertpub.com
In humans, most hearing loss results from death of hair cells, the mechanosensory receptors
of the inner ear. Two goals of current hearing research are to protect hair cells from …

Feathers and fins: non-mammalian models for hair cell regeneration

HR Brignull, DW Raible, JS Stone - Brain research, 2009 - Elsevier
Death of mechanosensory cells in the inner ear results in two profound disabilities: hearing
loss and balance disorders. Although mammals lack the capacity to regenerate hair cells …

Sensory hair cell development and regeneration: similarities and differences

PJ Atkinson, E Huarcaya Najarro, ZN Sayyid… - …, 2015 - journals.biologists.com
Sensory hair cells are mechanoreceptors of the auditory and vestibular systems and are
crucial for hearing and balance. In adult mammals, auditory hair cells are unable to …

Recent advancements in the regeneration of auditory hair cells and hearing restoration

R Mittal, D Nguyen, AP Patel, LH Debs… - Frontiers in molecular …, 2017 - frontiersin.org
Neurosensory responses of hearing and balance are mediated by receptors in specialized
neuroepithelial sensory cells. Any disruption of the biochemical and molecular pathways …

Molecular remodeling of tip links underlies mechanosensory regeneration in auditory hair cells

AA Indzhykulian, R Stepanyan, A Nelina… - PLoS …, 2013 - journals.plos.org
Sound detection by inner ear hair cells requires tip links that interconnect mechanosensory
stereocilia and convey force to yet unidentified transduction channels. Current models …

Hair cell regeneration in the bird cochlea following noise damage or ototoxic drug damage

DA Cotanche, KH Lee, JS Stone, DA Picard - Anatomy and embryology, 1994 - Springer
Hair cells are sensory cells that transduce motion into neural signals. In the cochlea, they
are used to detect sound waves in the environment and turn them into auditory signals that …