Noise-Induced Hearing Loss and Drug Therapy: Basic and Translational Science

C Escabi, M Trevino, E Bielefeld… - New Therapies to Prevent …, 2020 - Springer
Noise-induced hearing loss is the second leading cause of hearing impairment. The
purpose of this chapter is to familiarize the reader with the anatomical, physiological, and …

Noise-induced hearing loss and its prevention: Current issues in mammalian hearing

CG Le Prell, TA Hackett, R Ramachandran - Current opinion in physiology, 2020 - Elsevier
Highlights•Noise-induced hearing loss (NIHL) remains a major public health issue.•Studies
in animal models show that both sensory hair cells and cochlear synapses are vulnerable to …

Drug development for noise-induced hearing loss

I Varela-Nieto, S Murillo-Cuesta, M Calvino… - Expert opinion on …, 2020 - Taylor & Francis
Introduction Excessive exposure to noise is a common occurrence that contributes to
approximately 50% of the non-genetic hearing loss cases. Researchers need to develop …

Emerging treatments for noise-induced hearing loss

N Oishi, J Schacht - Expert opinion on emerging drugs, 2011 - Taylor & Francis
Introduction: Approximately 5% of the population worldwide suffers from industrial, military or
recreational noise-induced hearing loss (NIHL) at a great economic cost and detriment to …

Development of drugs for noise-induced hearing loss

ED Lynch, J Kil, CG Le Prell - … Research in Audiology, Neurotology, and the …, 2016 - Springer
Current efforts to translate laboratory findings into clinical drugs for preventing or treating
sensorineural hearing loss (SNHL) are reviewed in this chapter. Since no drugs have been …

Emerging therapeutic interventions against noise-induced hearing loss

SH Sha, J Schacht - Expert opinion on investigational drugs, 2017 - Taylor & Francis
Introduction: Noise-induced hearing loss (NIHL) due to industrial, military, and recreational
noise exposure is a major, but also potentially preventable cause of acquired hearing loss …

Prevention of noise-induced hearing loss: potential therapeutic agents

CG Le Prell, J Bao - Noise-induced hearing loss: Scientific advances, 2012 - Springer
Noise-induced hearing loss (NIHL) is a significant clinical, social, and economic issue. The
development of novel therapeutic agents to reduce NIHL would increase the potential …

Advances and challenges in pharmaceutical therapies to prevent and repair cochlear injuries from noise

EC Bielefeld, MJ Kobel - Frontiers in Cellular Neuroscience, 2019 - frontiersin.org
Noise induces a broad spectrum of pathological injuries to the cochlea, reflecting both
mechanical damage to the delicate architecture of the structures of the organ of Corti and …

[HTML][HTML] Noise-induced hearing disorders: Clinical and investigational tools

CG Le Prell, OH Clavier, J Bao - The Journal of the Acoustical Society …, 2023 - pubs.aip.org
A series of articles discussing advanced diagnostics that can be used to assess noise injury
and associated noise-induced hearing disorders (NIHD) was developed under the umbrella …

Pharmacological approaches to the prevention and treatment of cochlear injury due to noise

RD Kopke - Audiological Medicine, 2007 - Taylor & Francis
Sensorineural hearing loss (SNHL) due to the damaging effects of noise is the second
leading cause of SNHL, next to presbyacusis, in the industrialized world. It is the leading …