The scarcity of live human brain cells for experimental access has for a long time limited our
ability to study complex human neurological disorders and elucidate basic neuroscientific …

Cellular reprogramming is a new and rapidly emerging field in which somatic cells can be
turned into pluripotent stem cells or other somatic cell types simply by the expression of …

Differentiated cells have long been considered fixed in their identity. However, about 20
years ago, the first direct conversion of glial cells into neurons in vitro opened the field of" …

Cellular reprogramming is a rapidly developing technology by which somatic cells are
turned into pluripotent stem cells or other somatic cell types through expression of specific …

Background: Differentiated cells can be reprogrammed to switch identities from one cell type
to another under the direction of powerful transcription factors. In the mammalian central …

Regeneration of the nervous system requires either the repair or replacement of nerve cells
that have been damaged by injury or disease. While lower organisms possess extensive …

Direct neuronal reprogramming is an innovative new technology that involves the
conversion of somatic cells to induced neurons (iNs) without passing through a pluripotent …

Induced pluripotent stem cells and embryonic stem cells have revolutionized cellular
neuroscience, providing the opportunity to model neurological diseases and test potential …

Most of our current knowledge about cellular phenotypes in neurodevelopmental and
neurodegenerative diseases in humans was gathered from studies in postmortem brain …

Reprogramming of somatic cells into neurons provides a new approach toward cell-based
therapy of neurodegenerative diseases. A major challenge for the translation of neuronal …