Interferon regulatory factors (IRFs) constitute a family of transcription factors that commonly
possess a novel helix-turn-helix DNA-binding motif. Following the initial identification of two …

Transcription factors of the interferon regulatory factor (IRF) family commands the entire type
I interferon (IFN) system from induction of IFNs to diverse IFN responses, thereby providing a …

Members of the interferon-regulatory factor (IRF) proteins family were originally identified as
transcriptional regulators of the Type I interferon system. Thanks to consistent advances …

The interferon regulatory factor (IRF) family, consisting of nine members in mammals, was
identified in the late 1980s in the context of research into the type I interferon system …

Nine interferon regulatory factors (IRFs) compose a family of transcription factors in
mammals. Although this family was originally identified in the context of the type I interferon …

A family of transcription factors, the interferon regulatory factors (IRF), was identified
originally in the context of the regulation of the type I interferon (IFN)‐α/β system. The IRF …

Interferon (IFN) regulatory factor-1 (IRF-1) was isolated by virtue of its affinity to specific DNA
sequences in the IFN-β promoter that mediate virus responsiveness. IRF-1 was the first …

Transcription factors of the interferon (IFN) regulatory factor (IRF) family have been shown to
play an essential role in the regulated expression of type I IFN genes, IFN-stimulated genes …

Interferons are a large family of multifunctional secreted proteins involved in antiviral
defense, cell growth regulation and immune activation. Viral infection induces transcription …

We study a family of transcription factors, the interferon regulatory factors (IRFs), as originally
identified in the context of the regulation of type-I interferon (IFN-α/β) system. Most notably …