[HTML][HTML] Methylxanthines and neurodegenerative diseases: An update

D Janitschke, AA Lauer, CM Bachmann, HS Grimm… - Nutrients, 2021 - mdpi.com
Methylxanthines (MTX) are purine derived xanthine derivatives. Whereas naturally occurring
methylxanthines like caffeine, theophylline or theobromine are widely consumed in food …

Health benefits of methylxanthines in neurodegenerative diseases

A Oñatibia‐Astibia, R Franco… - Molecular nutrition & …, 2017 - Wiley Online Library
Methylxanthines (MTXs) are consumed by almost everybody in almost every area of the
world. Caffeine, theophylline and theobromine are the most well‐known members of this …

[HTML][HTML] Structure-bioactivity relationships of methylxanthines: Trying to make sense of all the promises and the drawbacks

JP Monteiro, MG Alves, PF Oliveira, BM Silva - Molecules, 2016 - mdpi.com
Methylxanthines are a group of phytochemicals derived from the purine base xanthine and
obtained from plant secondary metabolism. They are unobtrusively included in daily diet in …

Pharmacological potential of methylxanthines: Retrospective analysis and future expectations

J Monteiro, MG Alves, PF Oliveira… - Critical reviews in food …, 2019 - Taylor & Francis
Methylated xanthines (methylxanthines) are available from a significant number of different
botanical species. They are ordinarily included in daily diet, in many extremely common …

Impacts of methylxanthines and adenosine receptors on neurodegeneration: human and experimental studies

BB Fredholm, JF Chen, Y Chern - Methylxanthines, 2011 - Springer
Neurodegenerative disorders are some of the most feared illnesses in modern society, with
no effective treatments to slow or halt this neurodegeneration. Several decades after the …

The Effects and Mechanisms of Xanthones in Alzheimer's Disease: A Systematic Review

LW Pang, S Hamzah, SLJ Tan, SH Mah… - Neurochemical research, 2023 - Springer
Xanthones are natural secondary metabolites that possess great potential as
neuroprotective agents due to their prominent biological effects on Alzheimer's disease …

[HTML][HTML] Effect of caffeine and other methylxanthines on Aβ-homeostasis in SH-SY5Y cells

D Janitschke, C Nelke, AA Lauer, L Regner, J Winkler… - Biomolecules, 2019 - mdpi.com
Methylxanthines (MTX) are alkaloids derived from the purine-base xanthine. Whereas
especially caffeine, the most prominent known MTX, has been formerly assessed to be …

[HTML][HTML] Unique role of caffeine compared to other methylxanthines (theobromine, theophylline, pentoxifylline, propentofylline) in regulation of ad relevant genes in …

D Janitschke, AA Lauer, CM Bachmann… - International Journal of …, 2020 - mdpi.com
Methylxanthines are a group of substances derived from the purine base xanthine with a
methyl group at the nitrogen on position 3 and different residues at the nitrogen on position 1 …

[HTML][HTML] Identification and quantification of (poly) phenol and methylxanthine metabolites in human cerebrospinal fluid: evidence of their ability to cross the BBB

M Le Sayec, D Carregosa, K Khalifa, C de Lucia… - Food & Function, 2023 - pubs.rsc.org
Increasing evidence suggests that dietary (poly) phenols and methylxanthines have
neuroprotective effects; however, little is known about whether they can cross the blood …

Role of quercetin benefits in neurodegeneration

P Elumalai, S Lakshmi - The benefits of natural products for …, 2016 - Springer
Neurodegenerative disorders are often life threatening and hired as an economic burden to
the health-care system. Nutritional interventions principally involving polyphenols were …