Does the human placenta express the canonical cell entry mediators for SARS-CoV-2?

R Pique-Regi, R Romero, AL Tarca, F Luca, Y Xu… - Elife, 2020 - elifesciences.org
The pandemic of coronavirus disease 2019 (COVID-19) caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected more than 10 million …

Term human placental trophoblasts express SARS-CoV-2 entry factors ACE2, TMPRSS2, and furin

Y Ouyang, T Bagalkot, W Fitzgerald, E Sadovsky… - MSphere, 2021 - Am Soc Microbiol
ABSTRACT The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has had a massive impact on human …

Single-cell RNA-seq identifies cell subsets in human placenta that highly expresses factors driving pathogenesis of SARS-CoV-2

N Ashary, A Bhide, P Chakraborty, S Colaco… - Frontiers in cell and …, 2020 - frontiersin.org
Infection by the Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) results in
the novel coronavirus disease COVID-19, which has posed a serious threat globally …

Consistent localization of SARS-CoV-2 spike glycoprotein and ACE2 over TMPRSS2 predominance in placental villi of 15 COVID-19 positive maternal-fetal dyads

E Taglauer, Y Benarroch, K Rop, E Barnett… - Placenta, 2020 - Elsevier
Introduction While the COVID-19 pandemic continues to have a significant global health
impact, rates of maternal to infant vertical transmission remain low (< 5%). Parenchymal …

[HTML][HTML] The SARS-CoV-2 receptor ACE2 expression of maternal-fetal interface and fetal organs by single-cell transcriptome study

M Li, L Chen, J Zhang, C Xiong, X Li - PloS one, 2020 - journals.plos.org
The new type of pneumonia caused by the SARS-CoV-2 (Severe acute respiratory
syndrome coronavirus 2) has been declared as a global public health concern by WHO. As …

COVID‐19 and vertical transmission: assessing the expression of ACE2/TMPRSS2 in the human fetus and placenta to assess the risk of SARS‐CoV‐2 infection

MA Beesley, JR Davidson, F Panariello… - … Journal of Obstetrics …, 2022 - Wiley Online Library
Background Pregnant women have been identified as a potentially at‐risk group concerning
COVID‐19 infection, but little is known regarding the susceptibility of the fetus to infection …

Expression of SARS-CoV-2 receptor ACE2 and the protease TMPRSS2 suggests susceptibility of the human embryo in the first trimester

BAT Weatherbee, DM Glover… - Open …, 2020 - royalsocietypublishing.org
While initially recognized as causing respiratory disease, the SARS-CoV-2 virus also affects
many other organs leading to other complications. It has emerged that advanced age and …

[HTML][HTML] Clinical and in vitro evidence against placenta infection at term by severe acute respiratory syndrome coronavirus 2

A Colson, CL Depoix, G Dessilly, P Baldin… - The American journal of …, 2021 - Elsevier
Despite occasional reports of vertical transmission of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) during pregnancy, the question of placental infection and its …

Mechanisms and evidence of vertical transmission of infections in pregnancy including SARS‐CoV‐2s

AP Mahyuddin, A Kanneganti, JJL Wong… - Prenatal …, 2020 - Wiley Online Library
There remain unanswered questions concerning mother‐to‐child‐transmission of SARS‐
CoV‐2. Despite reports of neonatal COVID‐19, SARS‐CoV‐2 has not been consistently …

A message from the human placenta: structural and immunomodulatory defense against SARS-CoV-2

NN Kreis, A Ritter, F Louwen, J Yuan - Cells, 2020 - mdpi.com
The outbreak of the coronavirus disease 2019 (COVID-19) pandemic has caused a global
public health crisis. Viral infections may predispose pregnant women to a higher rate of …