Background Accurate, high-throughput genotyping allows the fine characterization of
genetic ancestry. Here we applied recently developed statistical and computational …

Background The ancestry of African-descended Americans is known to be drawn from three
distinct populations: African, European, and Native American. While many studies consider …

Quantifying patterns of population structure in Africans and African Americans illuminates
the history of human populations and is critical for undertaking medical genomic studies on …

We present a comprehensive assessment of genomic diversity in the African-American
population by studying three genotyped cohorts comprising 3,726 African-Americans from …

Over the past 500 years, North America has been the site of ongoing mixing of Native
Americans, European settlers, and Africans (brought largely by the trans-Atlantic slave …

African-American populations are genetically admixed. Studies performed among unrelated
individuals from ethnically admixed populations may be both vulnerable to confounding by …

A deeper appreciation of the complex architecture of African genomes is critical to the global
effort to understand human history, biology and differential distribution of disease by …

Coronary heart disease (CHD) is the leading cause of mortality in African Americans. To
identify common genetic polymorphisms associated with CHD and its risk factors (LDL-and …

The extent of recent selection in admixed populations is currently an unresolved question.
We scanned the genomes of 29,141 African Americans and failed to find any genome-wide …

The differential relative contribution of males and females from Africa and Europe to
individual African American genomes is relevant to mapping genes utilizing admixture …