Large extracellular vesicles: have we found the holy grail of inflammation?

A Słomka, SK Urban, V Lukacs-Kornek… - Frontiers in …, 2018 - frontiersin.org
The terms microparticles (MPs) and microvesicles (MVs) refer to large extracellular vesicles
(EVs) generated from a broad spectrum of cells upon its activation or death by apoptosis …

Macrophage-derived extracellular vesicles: diverse mediators of pathology and therapeutics in multiple diseases

Y Wang, M Zhao, S Liu, J Guo, Y Lu, J Cheng… - Cell death & …, 2020 - nature.com
Macrophages (Mφ) are primary innate immune cells that exhibit diverse functions in
response to different pathogens or stimuli, and they are extensively involved in the …

Emerging role of extracellular vesicles in inflammatory diseases

EI Buzas, B György, G Nagy, A Falus… - Nature Reviews …, 2014 - nature.com
The discovery that submicron-sized extracellular vesicles (EVs) are generated by both
prokaryotic and eukaryotic cells might have a profound effect on experimental and clinical …

Beyond macromolecules: extracellular vesicles as regulators of inflammatory diseases

K Das, S Paul, T Mukherjee, A Ghosh, A Sharma… - Cells, 2023 - mdpi.com
Inflammation is the defense mechanism of the immune system against harmful stimuli such
as pathogens, toxic compounds, damaged cells, radiation, etc., and is characterized by …

Platelet microvesicles in health and disease

I Melki, N Tessandier, A Zufferey, E Boilard - platelets, 2017 - Taylor & Francis
Interest in cell-derived extracellular vesicles and their physiological and pathological
implications is constantly growing. Microvesicles, also known as microparticles, are small …

Extracellular vesicles in neuroinflammation

G Marostica, S Gelibter, M Gironi, A Nigro… - Frontiers in cell and …, 2021 - frontiersin.org
Extracellular vesicles (EVs) are a heterogenous group of membrane-bound particles that
play a pivotal role in cell–cell communication, not only participating in many physiological …

The role of microparticles in inflammation and thrombosis

SP Ardoin, JC Shanahan… - Scandinavian journal of …, 2007 - Wiley Online Library
Microparticles (MP) are small membrane‐bound vesicles that circulate in the peripheral
blood and play active roles in thrombosis, inflammation and vascular reactivity. While MP …

Extracellular vesicle/macrophage axis: potential targets for inflammatory disease intervention

D Tang, F Cao, C Yan, K Fang, J Ma, L Gao… - Frontiers in …, 2022 - frontiersin.org
Extracellular vesicles (EVs) can regulate the polarization of macrophages in a variety of
inflammatory diseases by mediating intercellular signal transduction and affecting the …

Extracellular vesicles: packages sent with complement

E Karasu, SU Eisenhardt, J Harant… - Frontiers in …, 2018 - frontiersin.org
Cells communicate with other cells in their microenvironment by transferring lipids, peptides,
RNA, and sugars in extracellular vesicles (EVs), thereby also influencing recipient cell …

Microparticles: a critical component in the nexus between inflammation, immunity, and thrombosis

O Morel, N Morel, L Jesel, JM Freyssinet… - Seminars in …, 2011 - Springer
Plasma membrane remodeling characterized by phosphatidylserine exposure and
consecutive microparticle (MP) shedding is an ubiquitous process enabling the clearance of …