Systemic immunity supports lifelong brain function. Obesity posits a chronic burden on
systemic immunity. Independently, obesity was shown as a risk factor for Alzheimer's …

Introduction: Increasing evidence indicates that neurodegenerative diseases, including
Alzheimer's disease (AD), are a product of gene-by-environment interplay. The immune …

Recently, increasing evidence has suggested the association between gut dysbiosis and
Alzheimer's disease (AD) progression, yet the role of gut microbiota in AD pathogenesis …

More Americans are consuming diets higher in saturated fats and refined sugars than ever
before, and based on increasing obesity rates, this is a growing trend among older adults as …

Background Obesity rates are increasing worldwide. Obesity leads to many complications,
including predisposing individuals to the development of cognitive impairment as they age …

Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by a
concerning rise in prevalence. It is projected that the number of affected individuals will …

Alzheimer's disease (AD) is the most common form of dementia. Obesity in middle age
increases AD risk and severity, which is alarming given that obesity prevalence peaks at …

Systemic inflammation has been implicated in the progression of Alzheimer's disease (AD);
however, less is understood about how existing AD pathology contributes to adverse …

Alzheimer's disease (AD) is the most common neurodegenerative disease. Growing
evidence suggests an important role for gut dysbiosis and gut microbiota-host interactions in …

Alzheimer's disease (AD) is characterized by deficits in cerebral metabolic rates of glucose
in the posterior cingulate (PC) and precuneus in AD subjects, and in APOEε4 carriers …