Understanding tissue macrophage biology has become challenging in recent years due the
ever-increasing complexity in macrophage-subset identification and functional …

Highlights•Three resident cardiac macrophage subsets of differential origin and
lifecycles.•Recruited monocytes adopt numerous fates within injured myocardium.•Resident …

Cardiac macrophages are crucial for tissue repair after cardiac injury but are not well
characterized. Here we identify four populations of cardiac macrophages. At steady state …

Macrophages play critical roles in homeostatic maintenance of the myocardium under
normal conditions and in tissue repair after injury. In the steady-state heart, resident cardiac …

Cardiac macrophages are abundant in the healthy heart and after myocardial infarction (MI).
Different macrophage phenotypes likely promote myocardial health vs. disease. Infarct …

Macrophages are integral components of cardiac tissue and exert profound effects on the
healthy and diseased heart. Paradigm shifting studies using advanced molecular …

Resident cardiac macrophages (rcMacs) are integral components of the myocardium where
they have key roles for tissue homeostasis and in response to inflammation, tissue injury …

Monocytes and macrophages are innate immune cells that reside and accumulate in the
healthy and injured heart. The cells and their subsets pursue distinct functions in steady …

Macrophages were first described as phagocytic immune cells responsible for maintaining
tissue homeostasis by the removal of pathogens that disturb normal function. Historically …

Macrophages are essential components of the immune system and play a role in the normal
functioning of the cardiovascular system. Depending on their origin and phenotype, cardiac …