Molecular mechanisms of neurotoxicity induced by polymyxins and chemoprevention
Neurotoxicity is one major unwanted side-effects associated with polymyxin (ie, colistin and
polymyxin B) therapy. Clinically, colistin neurotoxicity is characterized by neurological …
polymyxin B) therapy. Clinically, colistin neurotoxicity is characterized by neurological …
Curcumin attenuates colistin-induced neurotoxicity in N2a cells via anti-inflammatory activity, suppression of oxidative stress, and apoptosis
Neurotoxicity is an unwanted side-effect seen in patients receiving therapy with the “last-
line” polymyxin antibiotics. This is the first study to show that colistin-induced neurotoxicity in …
line” polymyxin antibiotics. This is the first study to show that colistin-induced neurotoxicity in …
Rapamycin confers neuroprotection against colistin-induced oxidative stress, mitochondria dysfunction, and apoptosis through the activation of autophagy and mTOR …
Our previous studies showed that colistin-induced neurotoxicity involves apoptosis and
oxidative damage. The present study demonstrates a neuroprotective effect of rapamycin …
oxidative damage. The present study demonstrates a neuroprotective effect of rapamycin …
Minocycline attenuates colistin-induced neurotoxicity via suppression of apoptosis, mitochondrial dysfunction and oxidative stress
Background: Neurotoxicity is an adverse effect patients experience during colistin therapy.
The development of effective neuroprotective agents that can be co-administered during …
The development of effective neuroprotective agents that can be co-administered during …
Colistin induced peripheral neurotoxicity involves mitochondrial dysfunction and oxidative stress in mice
Polymyxin is a critical antibiotic against the infection caused by multidrug-resistant gram-
negative bacteria. Neurotoxicity is one of main dose-limiting factors. The present study …
negative bacteria. Neurotoxicity is one of main dose-limiting factors. The present study …
[HTML][HTML] Piceatannol-3′-O-β-D-glucopyranoside attenuates colistin-induced neurotoxicity by suppressing oxidative stress via the NRF2/HO-1 pathway
L Xiong, D Xiang, F Yuan, H Tong, R Yang… - Biomedicine & …, 2023 - Elsevier
Abstract Background Multidrug-resistant Gram-negative bacteria are the most pressing
problem in treating infectious diseases. As one of the primary drugs for multidrug-resistant …
problem in treating infectious diseases. As one of the primary drugs for multidrug-resistant …
Colistin-induced apoptosis of neuroblastoma-2a cells involves the generation of reactive oxygen species, mitochondrial dysfunction, and autophagy
Neurotoxicity remains a poorly characterized adverse effect associated with colistin therapy.
The aim of the present study was to investigate the mechanism of colistin-induced …
The aim of the present study was to investigate the mechanism of colistin-induced …
Prevention of colistin-induced neurotoxicity: a narrative review of preclinical data
S Soroudi, G Mousavi, F Jafari, S Elyasi - … -Schmiedeberg's Archives of …, 2024 - Springer
Polymyxin E or colistin is an effective antibiotic against MDR Gram-negative bacteria. Due to
unwanted side effects, the use of this antibiotic has been limited for a long time, but in recent …
unwanted side effects, the use of this antibiotic has been limited for a long time, but in recent …
Curcumin attenuates colistin-induced peripheral neurotoxicity in mice
Peripheral neurotoxicity often occurs in patients receiving parenteral polymyxin therapy (ie,
colistin methanesulfonate or polymyxin B). The present study aimed to investigate the …
colistin methanesulfonate or polymyxin B). The present study aimed to investigate the …
p53 mediates colistin-induced autophagy and apoptosis in PC-12 cells
L Zhang, D Xie, X Chen, MLR Hughes… - Antimicrobial Agents …, 2016 - Am Soc Microbiol
The mechanism of colistin-induced neurotoxicity is still unknown. Our recent study (L. Zhang,
YH Zhao, WJ Ding, GZ Jiang, ZY Lu, L. Li, JL Wang, J. Li, and JC Li, Antimicrob Agents …
YH Zhao, WJ Ding, GZ Jiang, ZY Lu, L. Li, JL Wang, J. Li, and JC Li, Antimicrob Agents …