Polygonum multiflorum: Recent updates on newly isolated compounds, potential hepatotoxic compounds and their mechanisms

T Teka, L Wang, J Gao, J Mou, G Pan, H Yu… - Journal of …, 2021 - Elsevier
Abstract Ethnopharmacological relevance Polygonum multiflorum Thunb.(PM),(known as
Heshouwu (何首乌) in China) is one of the most important and well mentioned Chinese …

The assessment of the chronic hepatotoxicity induced by Polygoni Multiflori Radix in rats: a pilot study by using untargeted metabolomics method

XH Xia, YY Yuan, M Liu - Journal of ethnopharmacology, 2017 - Elsevier
Abstract Polygoni Multiflori Radix is the dried root of Polygonum multiflorum Thunb officially
recorded in the Chinese Pharmacopoeia as HeShouWu (HSW) in Chinese pinyin. The …

Interpretation the Hepatotoxicity Based on Pharmacokinetics Investigated Through Oral Administrated Different Extraction Parts of Polygonum multiflorum on Rats

M Zhang, L Lin, H Lin, C Qu, L Yan, J Ni - Frontiers in Pharmacology, 2018 - frontiersin.org
The liver injury induced by Polygonum multiflorum (PM) used for clinical treatment has
recently received widespread attention. This study aimed to determine the hepatotoxicity of …

Hepatotoxicity and hepatoprotection of Polygonum multiflorum Thund. as two sides of the same biological coin

LY Ruan, MH Li, YX Xing, W Hong, C Chen… - Journal of …, 2019 - Elsevier
Abstract Ethnopharmacological relevance Polygonum multiflorum Thund., a well-known and
commonly-used TCM (Traditional Chinese Medicine) for treating hypertension …

Traditional usages, botany, phytochemistry, pharmacology and toxicology of Polygonum multiflorum Thunb.: a review

L Lin, B Ni, H Lin, M Zhang, X Li, X Yin, C Qu… - Journal of …, 2015 - Elsevier
Abstract Ethnopharmacological relevance Polygonum multiflorum Thunb., which is known
as Heshouwu (何首乌 in Chinese) in China. It is traditionally valued and reported for hair …

A review of the processed Polygonum multiflorum (Thunb.) for hepatoprotection: Clinical use, pharmacology and toxicology

X Xue, Y Quan, L Gong, X Gong, Y Li - Journal of Ethnopharmacology, 2020 - Elsevier
Abstract Ethnopharmacological relevance Polygonum multiflorum (Thunb.)(PMT) is a
member of Polygonaceae. Traditional Chinese medicine considers that the processed PMT …

Polygonum multiflorum-Induced Liver Injury: Clinical Characteristics, Risk Factors, Material Basis, Action Mechanism and Current Challenges

Y Liu, W Wang, M Sun, B Ma, L Pang, Y Du… - Frontiers in …, 2019 - frontiersin.org
Polygonum multiflorum Thunb.(PM), called Heshouwu in China, is a popular Chinese
medicine in clinical practice. Several clinical studies have been conducted to evaluate the …

Hepatoprotection and hepatotoxicity of Heshouwu, a Chinese medicinal herb: context of the paradoxical effect

H Li, X Wang, Y Liu, D Pan, Y Wang, N Yang… - Food and Chemical …, 2017 - Elsevier
Abstract Heshouwu (Polygonum multiflorum Thunb.) has been a common Chinese medicine
and a folk Taoist medicine for over a thousand years. There are two drug forms …

A stepwise strategy integrating metabolomics and pseudotargeted spectrum–effect relationship to elucidate the potential hepatotoxic components in Polygonum …

Y Song, J Yang, X Hu, H Gao, P Wang… - Frontiers in …, 2022 - frontiersin.org
Polygonum multiflorum (PM) Thunb., a typical Chinese herbal medicine with different
therapeutic effect in raw and processed forms, has been used worldwide for thousands of …

Investigation of Liver Injury of Polygonum multiflorum Thunb. in Rats by Metabolomics and Traditional Approaches

YX Li, XH Gong, MC Liu, C Peng, P Li… - Frontiers in …, 2017 - frontiersin.org
Liver injury induced by Polygonum multiflorum Thunb.(PM) have been reported since 2006,
which aroused widespread concern. However, the toxicity mechanism of PM liver injury …