Innovative approaches and advances for hair follicle regeneration

W Zheng, CH Xu - ACS Biomaterials Science & Engineering, 2023 - ACS Publications
Pathological hair loss (also known as alopecia) and shortage of hair follicle (HF) donors
have posed an urgent requirement for HF regeneration. With the revelation of mechanisms …

[HTML][HTML] Cells, growth factors and biomaterials used in tissue engineering for hair follicles regeneration

K Xu, E Yu, M Wu, P Wei, J Yin - Regenerative Therapy, 2022 - Elsevier
Alopecia is a common and distressing medical condition that has affected a majority of
people worldwide, which leads to great effects on the quality of life and self-esteem …

[HTML][HTML] Microenvironmental reprogramming of human dermal papilla cells for hair follicle tissue engineering

Z Liu, J Huang, D Kang, Y Zhou, L Du, Q Qu, J Wang… - Acta Biomaterialia, 2023 - Elsevier
The restoration of hair-inductive potential in human dermal papilla cells (hDPCs) is a
tremendous challenge for hair regeneration. Much of the research thus far has indicated that …

Nanoscale microenvironment engineering for expanding human hair follicle stem cell and revealing their plasticity

P Chen, F Zhang, Z Fan, T Shen, B Liu, R Chen… - Journal of …, 2021 - Springer
Background Periodically regenerated hair follicles provide an excellent research model for
studying tissue regeneration and stem cell homeostasis. Periodic activation and …

[HTML][HTML] Nanoscale microenvironment engineering based on layer-by-layer self-assembly to regulate hair follicle stem cell fate for regenerative medicine

P Chen, Y Miao, F Zhang, J Huang, Y Chen, Z Fan… - Theranostics, 2020 - ncbi.nlm.nih.gov
Hair regenerative medicine, a promising strategy for the treatment of hair loss, will likely
involve the transplantation of autologous hair follicular stem cells (HFSCs) and dermal …

The promising prospect of human hair follicle regeneration in the shadow of new tissue engineering strategies

AK Vandishi, A Esmaeili, N Taghipour - Tissue and Cell, 2024 - Elsevier
Hair loss disorder (alopecia) affects numerous people around the world. The low
effectiveness and numerous side effects of common treatments have prompted researchers …

Recreation of a hair follicle regenerative microenvironment: Successes and pitfalls

CM Abreu, AP Marques - Bioengineering & Translational …, 2022 - Wiley Online Library
The hair follicle (HF) is an exquisite skin appendage endowed with cyclical regenerative
capacity; however, de novo follicle formation does not naturally occur. Consequently …

Tissue engineering strategies for human hair follicle regeneration: How far from a hairy goal?

AR Castro, E Logarinho - Stem Cells Translational Medicine, 2020 - academic.oup.com
The demand for an efficient therapy for alopecia disease has fueled the hair research field in
recent decades. However, despite significant improvements in the knowledge of key …

Induction of dermal fibroblasts into dermal papilla cell-like cells in hydrogel microcapsules for enhanced hair follicle regeneration

B Xie, M Chen, P Ding, L Lei, X Zhang, D Zhu… - Applied Materials …, 2020 - Elsevier
Current approaches fail at obtaining adequate functional human dermal papilla cells (DPCs)
to regenerate hair follicles (HFs). Here we induce human dermal fibroblasts (hDFs) into …

3D bioprinting of a gelatin-alginate hydrogel for tissue-engineered hair follicle regeneration

D Kang, Z Liu, C Qian, J Huang, Y Zhou, X Mao, Q Qu… - Acta biomaterialia, 2023 - Elsevier
Hair follicle (HF) regeneration remains challenging, principally due to the absence of a
platform that can successfully generate the microenvironmental cues of hair neogenesis …