Thioredoxin-interacting protein (TXNIP) as a target for Alzheimer's disease: Flavonoids and phenols

M Zhang, G Hu, N Shao, Y Qin, Q Chen, Y Wang… - …, 2021 - Springer
Alzheimer's disease (AD) is a neurodegenerative disease characterized by amyloid plaques
and tangles that have become the fifth leading cause of death worldwide. Previous studies …

Thioredoxin-interacting protein (TXNIP) associated NLRP3 inflammasome activation in human Alzheimer's disease brain

L Li, S Ismael, S Nasoohi, K Sakata… - Journal of …, 2019 - content.iospress.com
Alzheimer's disease (AD) is the most common form of age-associated dementia
characterized by amyloid-ß plaques and neurofibrillary tangles. Recent studies have …

Thioredoxin-interacting protein (TXNIP) with focus on brain and neurodegenerative diseases

H Tsubaki, I Tooyama, DG Walker - International journal of molecular …, 2020 - mdpi.com
The development of new therapeutic approaches to diseases relies on the identification of
key molecular targets involved in amplifying disease processes. One such molecule is …

Upregulation of thioredoxin-interacting protein in brain of amyloid-β protein precursor/presenilin 1 transgenic mice and amyloid-β treated neuronal cells

Y Wang, Y Wang, V Bharti, H Zhou… - Journal of …, 2019 - content.iospress.com
Oxidative stress has been hypothesized to play a role in the pathophysiology of Alzheimer's
disease (AD). Previously, we found that total nitrosylated protein levels were increased in …

Phytochemicals as potential target on thioredoxin-interacting protein (TXNIP) for the treatment of cardiovascular diseases

P Zhou, Y Ma, X Zhao, F Hua - Inflammopharmacology, 2023 - Springer
Cardiovascular diseases (CVDs) are currently the major cause of death and morbidity on a
global scale. Thioredoxin-interacting protein (TXNIP) is a marker related to metabolism …

Dl-3-n-Butylphthalide Inhibits NLRP3 Inflammasome and Mitigates Alzheimer's-Like Pathology via Nrf2-TXNIP-TrX Axis

CY Wang, Y Xu, X Wang, C Guo, T Wang… - Antioxidants & redox …, 2019 - liebertpub.com
Aims: Oxidative stress and neuroinflammation play important roles in the pathology of
Alzheimer's disease (AD). Thioredoxin-interacting protein (TXNIP), an endogenous inhibitor …

Thioredoxin-interacting protein (TXNIP) in cerebrovascular and neurodegenerative diseases: regulation and implication

S Nasoohi, S Ismael, T Ishrat - Molecular neurobiology, 2018 - Springer
Neurological diseases, including acute attacks (eg, ischemic stroke) and chronic
neurodegenerative diseases (eg, Alzheimer's disease), have always been one of the …

[HTML][HTML] TXNIP contributes to induction of pro-inflammatory phenotype and caspase-3 activation in astrocytes during Alzheimer's diseases

J Kim, J Lim, ID Yoo, S Park, JS Moon - Redox Biology, 2023 - Elsevier
Neuroinflammation and oxidative stress have been implicated in the pathogenesis of
Alzheimer's disease (AD). Neuroinflammation and oxidative stress are associated with …

ER stress associated TXNIP-NLRP3 inflammasome activation in hippocampus of human Alzheimer's disease

S Ismael, K Sakata, MP McDonald, FF Liao… - Neurochemistry …, 2021 - Elsevier
Although the exact etiology of Alzheimer's disease (AD) is poorly understood, experimental
and clinical evidences suggest the contribution of neuroinflammation in the pathogenesis of …

Quinones as preventive agents in Alzheimer's diseases: focus on NLRP3 inflammasomes

D Chen, H Gao, C Peng, S Pei, A Dai… - Journal of Pharmacy …, 2020 - academic.oup.com
Objectives Alzheimer's disease (AD) is a hidden neurological degenerative disease, which
main clinical manifestations are cognitive dysfunction, memory impairment and mental …