Emerging data have demonstrated that 5-methylcytosine (5-mC) and its oxidized products 5-
hydroxymethylcytosine (5-hmC), 5-formylcytosine (5-fC), and 5-carboxylcytosine (5-CaC) …

Discovery of the enzymatic activity that catalyses oxidation of 5-methylcytosine (5mC) to
generate 5-hydroxymethylcytosine (5hmC) mediated by the MLL (KMT2A) fusion partner …

The patterns of DNA methylation in human cancer cells are highly abnormal and often
involve the acquisition of DNA hypermethylation at hundreds or thousands of CpG islands …

DNA methylation is widely studied in the context of cancer. However, the rediscovery of 5-
hydroxymethylation of DNA adds a new layer of complexity to understanding the epigenetic …

methylcytosine (5‐mC) and 5‐hydroxymethylcytosine (5‐hmC) play a critical role in
development and normal physiology. Alterations in 5‐mC and 5‐hmC patterns are common …

Prior to 2009, 5-methylcytosine (5-mC) was thought to be the only biologically significant
cytosine modification in mammalian DNA. With the discovery of the TET enzymes, which …

DNA methylation at the fifth position of cytosines (5mC) represents a major epigenetic
modification in mammals. The recent discovery of 5-hydroxymethylcytosine (5hmC) …

Background The DNA modification 5-hydroxymethylcytosine (5hmC) is now referred to as
the sixth base of DNA with evidence of tissue-specific patterns and correlation with gene …

Ten-eleven translocation (TET) enzymes catalyze the oxidation of 5-methylcytosine (5-mC)
to 5-hydroxymethylcytosine (5-hmC) and then to 5-formylcytosine (5-fC) and 5 …

Early detection and characterization of molecular events associated with tumorgenesis
remain high priorities. Genome-wide epigenetic assays are promising diagnostic tools, as …