CPAP-induced airway hyper-reactivity in mice is modulated by hyaluronan synthase-3

CA Mayer, A Ganguly, A Mayer, CM Pabelick… - Pediatric …, 2022 - nature.com
Background Continuous positive airway pressure (CPAP) is a primary mode of respiratory
support for preterm infants. Animal studies have shown long-term detrimental effects on …

CPAP protects against hyperoxia-induced increase in airway reactivity in neonatal mice

PM MacFarlane, CA Mayer, A Jafri, CM Pabelick… - Pediatric …, 2021 - nature.com
Background Oxygen and continuous positive airway pressure (CPAP) are primary modes of
respiratory support for preterm infants. Animal models, however, have demonstrated …

Calcium-sensing receptor and CPAP-induced neonatal airway hyperreactivity in mice

CA Mayer, B Roos, J Teske, N Wells, RJ Martin… - Pediatric …, 2022 - nature.com
Background Continuous positive airway pressure (CPAP) in preterm infants is initially
beneficial, but animal models suggest longer term detrimental airway effects towards …

Increased airway reactivity in a neonatal mouse model of continuous positive airway pressure

CA Mayer, RJ Martin, PM MacFarlane - Pediatric research, 2015 - nature.com
Background: Continuous positive airway pressure (CPAP) is a primary form of respiratory
support used in the intensive care of preterm infants, but its long-term effects on airway (AW) …

Intra-amniotic LPS amplifies hyperoxia-induced airway hyperreactivity in neonatal rats

CW Choi, BI Kim, SN Mason, EN Potts-Kant… - Pediatric …, 2013 - nature.com
Background: We previously showed that intra-amniotic lipopolysaccharide (LPS) amplifies
alveolar hypoplasia induced by postnatal hyperoxia. We determined whether the priming …

Elevated Urine Hyaluronan Concentrations Are Associated with an Unfavorable Respiratory Outcome in Preterm Neonates at 40 Weeks Postmenstrual Age

PM MacFarlane, Z Chen, N Minich, CA Mayer… - Neonatology, 2024 - karger.com
Introduction: Hyaluronan (HA) is a major component of the extracellular matrix. Increased
pulmonary HA concentrations are associated with several respiratory disorders and is a …

Effects of antenatal lipopolysaccharide and postnatal hyperoxia on airway reactivity and remodeling in a neonatal mouse model

A Faksh, RD Britt, ER Vogel, I Kuipers… - Pediatric …, 2016 - nature.com
Background: Antenatal inflammation and preterm birth are associated with the development
of airway diseases such as wheezing and asthma. Utilizing a newborn mouse model, we …

A systematic review of the influence of continuous positive airway pressure on fetal and newborn animal models: suggestions to improve neonatal respiratory care

AG Gie, TR Hubble, Y Regin, T Salaets, M Zamora… - Neonatology, 2021 - karger.com
Introduction: Prematurely born infants regularly develop respiratory distress syndrome and
require assisted ventilation. Ventilation may injure the premature lung and increase the risk …

The effect of continuous positive airway pressure in a mouse model of hyperoxic neonatal lung injury

B Reyburn, JM Di Fiore, T Raffay, RJ Martin… - Neonatology, 2015 - karger.com
Background: Continuous positive airway pressure (CPAP) and supplemental oxygen have
become the mainstay of neonatal respiratory support in preterm infants. Although oxygen …

The receptor for hyaluronan-mediated motility (RHAMM) expression in neonatal bronchiolar epithelium correlates negatively with lung air content

L Markasz, RC Savani, G Sedin, R Sindelar - Early Human Development, 2018 - Elsevier
Introduction Hyaluronan (HA) and the receptor for hyaluronan-mediated motility (RHAMM)
may play an important role in lung development. We examined the expression of HA content …