We propose to approach SSc as a multistep immune-mediated disease that is in need of a
therapeutic strategy designed to interfere with one or more of these aberrant molecular …

A better understanding of SSc pathogenesis will allow the development of novel therapeutic
strategies targeting specific cell types and the pathways that are abnormally activated as …

Systemic sclerosis (SSc) is characterized by tissue fibrosis, obliterative microangiopathy,
and immune abnormalities. The role of autoimmunity in generating the clinical and …

Abstract Purpose of Review Systemic sclerosis (SSc) is a heterogeneous autoimmune
disease which has defined three hallmarks: Small vessel vasculopathy, production of …

Systemic sclerosis (SSc) is a complex rheumatologic autoimmune disease in which
inflammation, fibrosis, and vasculopathy share several pathogenic pathways that lead to …

Systemic sclerosis (SSc or scleroderma) is a progressive and highly debilitating
autoimmune disorder characterized by inflammation, vasculopathy, and extensive fibrosis …

In the field of genetics of SSc, we are currently reaching a period of rapid data production.
Several themes are already rising from the first wave of results. First, some genetic variants …

Systemic sclerosis is an autoimmune disease characterised by vascular dysfunction,
impaired angiogenesis, inflammation and fibrosis. There is no currently accepted disease …

Pathogenic processes that underlie the development and progression of systemic sclerosis
(SSc) are being defined in preclinical, clinical and genetic studies. Important evidence of …

OBJECTIVES: Systemic sclerosis (SSc) is a chronic connective tissue disease characterized
by vascular damage, autoimmunity, and excessive collagen deposition. Despite advances in …