Large-scale genetic interaction (GI) screens in yeast have been invaluable for our
understanding of molecular systems biology and for characterizing novel gene function …

The ease of performing both forward and reverse genetics in Saccharomyces cerevisiae,
along with its stable haploid state and short generation times, has made this budding yeast …

Systematic screens for genetic interactions are a cornerstone of both network and systems
biology. However, most screens have been limited to characterizing interaction networks in …

Genetic interactions are highly informative for deciphering the underlying functional
principles that govern how genes control cell processes. Recent developments in Synthetic …

Synthetic genetic arrays have been very effective at measuring genetic interactions in yeast
in a high-throughput manner and recently have been expanded to measure quantitative …

Providing access to quantitative genomic data is key to ensure large-scale data validation
and promote new discoveries. TheCellMap. org serves as a central repository for storing and …

Background Genetic interactions, or non-additive effects between genes, play a crucial role
in many cellular processes and disease. Which mechanisms underlie these genetic …

INTRODUCTION Genetic interactions are identified when variants in different genes
combine to generate an unusual phenotype compared with the expected combined effect of …

Genetic interactions mediate the emergence of phenotype from genotype. The systematic
survey of genetic interactions in yeast showed that genes operating in the same biological …

Deep mutational scanning (DMS) generates mutants of a protein of interest in a
comprehensive manner. CRISPR-Cas9 technology enables large-scale genome editing …