Hydroxycamptothecin (HCPT) is a natural plant alkaloid from Camptotheca that shows
potent antitumor activity by targeting intracellular topoisomerase I. However, factors such as …

Camptothecin (CPT), a natural plant alkaloid, has indicated potent antitumor activities via
targeting intracellular topoisomerase I. The promise that CPT holds in therapies is restricted …

The drug camptothecin has a wide range of antitumor effects in cancers including gastric
cancer, rectal and colon cancer, liver cancer, and lung cancer. Camptothecin-based drugs …

10-Hydroxycamptothecin (10-HCPT) is a promising anticancer drug with a wide spectrum of
antitumor activities. Due to its poor solubility, the carboxylate form that shows high water …

Camptothecin (CPT) is a cytotoxic alkaloid that attenuates the replication cancer cells via
blocking DNA topoisomerase 1. Despite its encouraging and wide spectrum antitumour …

DNA topoisomerase is one of drug targets in cancer therapy. Camptothecin is a plant
alkaloid derived from the Chinese tree Camptotheca acuminate. It has been demonstrated …

Camptothecin (CPT) is a potent, broad spectrum antitumor agent that inhibits the activity of
DNA topoisomerase I. Due to its poor solubility and stability and consequent delivery …

Hydroxycamptothecin (HCPT) has shown activity against a broad spectrum of cancers, but
its therapeutic efficacy is impaired by its poor solubility and delivery challenges. In this study …

In this study, polyethylene glycol (PEG) ylated 10-hydroxycamptothecin (mPEG1000-HCPT)
was synthesized and used as a stabilizer to prepare 10-hydroxycamptothecin (HCPT) …

Background Hydroxycamptothecin (HCPT) has been shown to have activity against a broad
spectrum of cancers. In order to enhance its tissue-specific delivery and anticancer activity …