Objective—Aldosterone (Aldo) is involved in arterial stiffness and heart failure, but the
mechanisms have remained unclear. Galectin-3 (Gal-3), a β-galactoside-binding lectin …

Hypertensive cardiac remodeling is accompanied by molecular inflammation and fibrosis, 2
mechanisms that finally affect cardiac function. At cardiac level, aldosterone promotes …

Objectives: This study investigated whether galectin (Gal)-3 inhibition could block
aldosterone-induced cardiac and renal fibrosis and improve cardiorenal dysfunction …

Galectin-3 (Gal-3) is involved in inflammation, fibrogenesis, and cardiac remodeling.
Previous evidence shows that Gal-3 interacts with aldosterone in promoting macrophage …

Context Patients with primary aldosteronism are associated with increased myocardial
fibrosis. Galectin-3 is one of the most important mediators between macrophage activation …

Background Aortic stenosis (AS) is a chronic inflammatory disease, and calcification plays
an important role in the progression of the disease. Galectin‐3 (Gal‐3) is a proinflammatory …

Remodeling, diastolic dysfunction, and arterial stiffness are some of the alterations through
which obesity affects the cardiovascular system. Fibrosis and inflammation are important …

Abstract Galectin-3 (Gal-3), a member of the β-galactoside lectin family, has an important
role in immune regulation. In hypertensive rats and heart failure patients, Gal-3 is …

Pathological vascular remodeling is the underlying cause of atherosclerosis and abdominal
aortic aneurysm (AAA). Here, we analyzed the role of galectin-1 (Gal-1), a β-galactoside …

A defining characteristic of pulmonary hypertension (PH) is the extensive remodeling of
pulmonary arteries (PAs), which results in progressive increases in vascular resistance and …