Normal homeostatic functions of adult stem cells have rhythmic daily oscillations that are
believed to become arrhythmic during aging. Unexpectedly, we find that aged mice remain …

The circadian clock temporally organizes cellular physiology throughout the day, allowing
daily environmental changes to be anticipated and potentially harmful physiologic …

Stem cells play central roles in tissue development, homeostasis, and regeneration.
Decades of scientific research have uncovered processes of stem cell decline in tissue and …

Cellular circadian clocks direct a daily transcriptional program that supports homeostasis
and resilience. Emerging evidence has demonstrated age-associated changes in circadian …

The process of aging and circadian rhythms are intimately intertwined, but how peripheral
clocks involved in metabolic homeostasis contribute to aging remains unknown. Importantly …

Adult stem cells exist in most mammalian organs and tissues and are indispensable for
normal tissue homeostasis and repair. In most tissues, there is an age-related decline in …

Tissue homeostasis and regenerative capacity rely on rare populations of somatic stem cells
endowed with the potential to self-renew and differentiate. During aging, many tissues show …

Stem cell aging and exhaustion are considered important drivers of organismal aging. Age-
associated declines in stem cell function are characterized by metabolic and epigenetic …

All multicellular organisms undergo a decline in tissue and organ function as they age. An
attractive theory is that a loss in stem cell number and/or activity over time causes this …

Stem cells are required for lifelong homeostasis and regeneration of tissues and organs in
mammals, but the function of stem cells declines during aging. To preserve stem cells during …